2012 Fiscal Year Final Research Report
HIV-1 Rev protein remodels viral export RNP
| Project/Area Number |
23790501
|
|---|
| Research Category |
Grant-in-Aid for Young Scientists (B)
|
| Allocation Type | Multi-year Fund |
|---|
| Research Field |
Virology
|
|---|
| Research Institution | Kyoto University |
|---|
Principal Investigator |
|
|---|
| Project Period (FY) |
2011 – 2012
|
| Keywords | RNA 核外輸送 |
|---|
| Research Abstract |
Human immunodeficiency virus type 1 (HIV-1) Rev protein induces export of the singly spliced and the unspliced HIV-1 transcripts. However, how these RNAs are exported is not well understood, since such transcripts should have both the transcription/export (TREX)complex and Rev on the same RNA, and therefore should have possibility of utilizing the TAP-dependent or CRM1-dependent export, or both. When HIV-1 transcripts were expressed in HEK293T cells, it was suggested that Rev suppresses the TAP recruitment to those transcripts. We also found that Rev interacts with the cap-binding complex (CBC) and inhibits the recruitment of Aly/REF, an adaptor for the TAP-dependent export.
|
