2012 Fiscal Year Final Research Report
Producing mechanism and function of IFN-λin nasal epithelial cells infected with RS-virus.
| Project/Area Number |
23790507
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Multi-year Fund |
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| Research Field |
Virology
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| Research Institution | Osaka University |
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Principal Investigator |
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| Project Period (FY) |
2011 – 2012
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| Keywords | RS ウイルス / hTERT 導入ヒト正常細胞 / 自然免疫 |
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| Research Abstract |
We reported that IFN-λ is the predominant IFN induced from RSV infected nasal epithelial cells. However, there were no-significant difference between IFN-λand IFN-βin nasal discharge of RSV-infected child. Streptococcus pneumonia and chemokines in nasal discharge were detected. Humuleone, the main constituent of hop bitter acids, inhibited RSV replication and chemokines production, and Clarithromycis, antimicrobial agent, inhibited chemokines production and PAF expressioni, which is the receptor of S. pneumonia. These results suggested new treatment approach to RSV infection.
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[Journal Article] Humulone suppress replication of RSV and release of IL-8 and RANTES in normal human nasal epithelial cells2013
Author(s)
Fuchimoto J, Kojima T, Okabayashi T, Masaki T, Ogasawara N, Obata K, Nomura K, Hirakawa S, Kobayashi N, Yokota SI, Fujii N, Tsutsumi H, Himi T, Sawada N
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Journal Title
DOI
Peer Reviewed
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