2013 Fiscal Year Final Research Report
Analysis of mechanisms by which CX3CR1high myeloid cells regulate gut homeostais
| Project/Area Number |
23790536
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Multi-year Fund |
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| Research Field |
Immunology
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| Research Institution | Osaka University |
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Principal Investigator |
KAYAMA Hisako 大阪大学, 医学(系)研究科(研究院), 助教 (40548814)
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| Project Period (FY) |
2011 – 2013
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| Keywords | 腸管免疫 / 自然免疫 |
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| Research Abstract |
We have identified that CX3CR1high CD11b+ CD11c+ myeloid cells (regulatory myeloid cells: Mreg cells) preferentially interacted with effector T cells via high expression of ICAM-1/VCAM, but did not activate effector T cells owing to the IL-10/Stat3-dependent suppression of CD80 and CD86 expression. In addition, our study showed that the severity of intestinal inflammation was improved by administration of wild-type Mreg cells in LysM-cre; Stat3flox/flox mice with Mreg cells lacking suppressive activity. These findings indicate the possibility that the impaired Mreg function is responsible for onset or/and progression of IBD.
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[Journal Article] Intestinal CX3C chemokine receptor 1high (CX3CR1high) myeloid cells prevent T-cell-dependent colitis2012
Author(s)
Kayama H, Ueda Y, Sawa Y, Jeon SG, Ma JS, Okumura R, Kubo A, Ishii M, Okazaki T, Murakami M, Yamamoto M, Yagita H, Takeda K
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Journal Title
Proc Natl Acad Sci USA
Volume: 109 (13)
Pages: 5010-5015
DOI
Peer Reviewed
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