AhR regulates innate immune responses and Th17 cell differentiation

2012 Fiscal Year Final Research Report

• Project/Area Number: 23790545
• Research Category: Grant-in-Aid for Young Scientists (B)
• Allocation Type: Multi-year Fund
• Research Field: Immunology
• Research Institution: Keio University
• Principal Investigator: KIMURA Akihiro 慶應義塾大学, 医学部, 助教 (20533318)
• Project Period (FY): 2011 – 2012
• Keywords: ダイオキシン受容体 / listeria monocytogenes / 活性酸素 / マクロファージ

Research Abstract

AhR plays an important role in the host defense against Listeria monocytogenes(LM) infection. While AhR suppresses LM-induced pro-inflammatory cytokine production, AhR inhibits the cell death of macrophages infectedwith LM. In addition, AhR participates i

Research Products

• [Journal Article] Nr4a receptors are essential for thymic regulatory T cell development and immune homeostasis (2013)
  • Author(s): Sekiya T, Kashiwagi I,Yoshida R, Fukaya T, Morita R, Kimura A, Ichinose H, Metzger D, Chambon P, Yoshimura A
  • Journal Title: Nat Immunol Volume: 14 Pages: 230-7
  • DOI: doi:10.1038/ni.2520
  • Peer Reviewed
• [Journal Article] IL-23-independent induction of IL-17 from γδT cells and innate lymphoid cells promotes experimental intraocular neovascularization. (2013)
  • Author(s): Hasegawa E, Sonoda KH, Shichita T, Morita R, Sekiya T, Kimura A, Oshima Y, Takeda A, Yoshimura T, Yoshida S, Ishibashi T, Yoshimura A
  • Journal Title: J Immunol Volume: 190 Pages: 1778-87
  • DOI: doi:10.4049/jimmunol.1202495
  • Peer Reviewed
• [Journal Article] Forced expression of stabilized c-Fos in dendritic cells reduces cytokine production and immune responses in vivo (2012)
  • Author(s): Yoshida R, Suzuki M, Sakaguchi R,Hasegawa E, Kimura A, Shichita T, Sekiya T, Shiraishi H, Shimoda K, Yoshimura A
  • Journal Title: Biochem Biophys Res Commun Volume: 423 Pages: 247-52
  • DOI: doi:10.1016/j.bbrc.2012.05.097
  • Peer Reviewed
• [Journal Article] Peroxiredoxin family proteins are key initiators of post-ischemic inflammation in the brain (2012)
  • Author(s): Shichita T, HasegawaE, Kimura A, Morita R, Sakaguchi R, Takada I, Sekiya T, Ooboshi H, Kitazono T, Yanagawa T, Ishii T, Takahashi H, Mori S, Nishibori M, Kuroda K, Akira S, Miyake K, Yoshimura A
  • Journal Title: Nat Med Volume: 18 Pages: 911-917
  • DOI: doi:10.1038/nm.2749
  • Peer Reviewed
• [Journal Article] Smad2 and Smad3 are redundantly essential for the suppression of iNOS synthesis in macrophages by regulating IRF3 and STAT1 pathways (2012)
  • Author(s): Sugiyama Y, Kakoi K, Kimura A, Takada I, Kashiwagi I, Wakabayashi Y, Morita R, Nomura M, Yoshimura A
  • Journal Title: Int Immunol Volume: 24 Pages: 253-265
  • DOI: doi:10.1093/intimm/dxr126
  • Peer Reviewed
• [Journal Article] Low dose CP-690,550 (tofacitinib), a pan-JAK inhibitor, accelerates the onset of experimental autoimmune encephalomyelitis by potentiating Th17 differentiation. (2012)
  • Author(s): Yoshida H, Kimura A, Fukaya T, Sekiya T, Morita R, Shichita T, Inoue H, Yoshimura A
  • Journal Title: Biochem Biophys Res Commun Volume: 418 Pages: 234-240
  • DOI: doi:10.1016/j.bbrc.2011.
  • Peer Reviewed
• [Journal Article] SOCS1 is essential for regulatory T cell functions by preventing loss of Foxp3 expression as well as IFN-{gamma} and IL-17A production (2011)
  • Author(s): Takahashi R, Nishimoto S, Muto G, Sekiya T, Tamiya T, Kimura A, Morita R, Asakawa M, Chinen T, Yoshimura A
  • Journal Title: J Exp Med Volume: 208 Pages: 2055-2067
  • DOI: doi:10.1084/jem.20110428
  • Peer Reviewed
• [Journal Article] Aryl hydrocarbon receptor negatively regulates LPS-induced IL-6 production through suppression of histamine production in macrophages (2011)
  • Author(s): Masuda K, Kimura A, Hanieh H, Nguyen NT, Nakahama T, Chinen I, Otoyo Y, Murotani T, Yamatodani A, Kishimoto T.
  • Journal Title: Int Immunol Volume: 23 Pages: 637-645
  • DOI: doi:10.1093/intimm/dxr072
  • Peer Reviewed
• [Journal Article] Aryl hydrocarbon receptor deficiency in T cells suppresses the development of collagen-induced arthritis (2011)
  • Author(s): Nakahama T, Kimura A, Nguyen NT, Chinen I, Hanieh H, Nohara K, Fujii-Kuriyama Y, Kishimoto T.
  • Journal Title: Proc Natl Acad Sci USA Volume: 108 Pages: 14222-14227
  • DOI: doi:10.1073/pnas.1111786108.
  • Peer Reviewed
• [Journal Article] Transcription Factor Smad-Independent T Helper 17 Cell Induction by Transforming-Growth Factor-βIs Mediated by Suppression of Eomesodermin. (2011)
  • Author(s): Ichiyama K, Sekiya T, Inoue N, Tamiya T, Kashiwagi I, Kimura A, Morita R, Muto G, Shichita T, Takahashi R, Yoshimura A
  • Journal Title: Immunity Volume: 34 Pages: 741-754
  • DOI: doi:10.1016/j.immuni.2011.02.021
  • Peer Reviewed
• [Presentation] Aryl hydrocarbon receptor is important for macrophage survival and protection against Listeria monocytogenesinfection (2012)
  • Author(s): 木村彰宏、吉村昭彦
  • Organizer: 第41回日本免疫学会総会
  • Place of Presentation: 神戸国際会議場
  • Year and Date: 2012-12-06
• [Presentation] Aryl hydrocarbon receptor regulates innateimmune responses to Listeria monocytogenes. (2011)
  • Author(s): 木村彰宏、吉村昭彦
  • Organizer: 第40回日本免疫学会総会
  • Place of Presentation: 幕張メッセ
  • Year and Date: 2011-12-03
• [Presentation] Aryl hydrocarbon receptor regulates innate immune responses to Listeria monocytogenes (2011)
  • Author(s): Akihiro Kimura, Akihiko Yoshimura
  • Organizer: 9th Joint Meeting of the ICS/ISICR Firenze
  • Place of Presentation: Italy
  • Year and Date: 2011-10-10
• [Presentation] ダイオキシン-ダイオキシン受容体によるT細胞分化制御機構の解明 (2011)
  • Author(s): 木村彰宏、吉村昭彦
  • Organizer: 第6回日本ケミカルバイオロジー学会
  • Place of Presentation: 東京工業大学大岡山キャンパス
  • Year and Date: 2011-05-24
• [Book] Th17細胞の分化とIL-6の役割. 臨床免疫・アレルギー科、59 (2013)
  • Author(s): 木村彰宏
  • Total Pages: 40-43
  • Publisher: 科学評論社
• [Book] Aryl hydrocarbon receptor/IDO産生樹状細胞によるレギュラトリーT細胞の誘導. 臨床免疫・アレルギー科、57 (2012)
  • Author(s): 木村彰宏
  • Total Pages: 371-376
  • Publisher: 科学評論社
• [Remarks] 科学評論社
  • URL: http://new.immunoreg.jp/