2013 Fiscal Year Final Research Report
Regulatory role of CRTAM+CD4+T cells in the mucosal immunity
| Project/Area Number |
23790551
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Multi-year Fund |
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| Research Field |
Immunology
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| Research Institution | The Institute of Physical and Chemical Research |
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Principal Investigator |
TAKEUCHI Arata 独立行政法人理化学研究所, 統合生命医科学研究センター, 研究員 (00360579)
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| Project Period (FY) |
2011 – 2013
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| Keywords | 細胞接着因子 / 細胞傷害活性 / 粘膜免疫 |
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| Research Abstract |
We previously identified an adhesion molecule CRTAM that is expressed on activated lymphocytes. Most of the T cells belong to one of two subset, these are CD8+ cytotoxic T cells and CD4+ helper T cells. In this study, we found that a small fraction of activated CD4+T cells express CRTAM. The gene expression profiles revealed that CRTAM+CD4+T cells shear both characteristics of helper and cytotoxic T cells. CRTAM+CD4+T cells are accumulated to intestine, and function during immune response. However, they worsen a symptom when colitis is induced.
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