2012 Fiscal Year Final Research Report
Elucidation of new reactivation mechanisms of influenza virus specific memory B cells in mouse model for influenza infection
Project/Area Number |
23790553
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Research Category |
Grant-in-Aid for Young Scientists (B)
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Allocation Type | Multi-year Fund |
Research Field |
Immunology
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Research Institution | National Institute of Infectious Diseases |
Principal Investigator |
ONODERA Taishi 国立感染症研究所, 免疫部, 主任研究官 (90513143)
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Project Period (FY) |
2011 – 2012
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Keywords | 記憶B細胞 / Toll様受容体 / ワクチン / インフルエンザウイルス |
Research Abstract |
Rapid production of high affinity antibodies by memory B cells, which are generated by prior vaccination and/or infection, plays an important role to improve mortality and morbidity in acute infectious diseases as influenza virus infection. In this study, we showed that memory B cells could produce high neutralizing antibodies against influenza virus more rapidly in CD4+ helper T cells independent way. Moreover, this reactivation mechanism was totally dependent upon B-cell intrinsic TLR7-MyD88 signaling, which is elicited by ssRNA included in virus particles. These findings provide insight into the new reactivating mechanisms of virus-specific memory B cells, together the development of new vaccine strategy to preferentially elicit high affinity antibodies from pre-existing memory B cell pool by booster vaccination.
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Research Products
(8 results)
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[Presentation] Memory B cells in the lung participate in protective humoral immune responses to pulmonary influenza virus reinfection2012
Author(s)
Takahashi, Y.Onodera, T., Yokoi, Y., Ato, M.,Hachimura, S., Kurosaki, T., Kobayashi, K
Organizer
Keystone symposia, Viral Immunity and Host Gene Influence
Place of Presentation
Colorado, USA
Year and Date
2012-03-25
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