Molecular mechanism for sustention of placental function by ezrinand a new approach to prevention of fetal growth retardation

2012 Fiscal Year Final Research Report

• Project/Area Number: 23790606
• Research Category: Grant-in-Aid for Young Scientists (B)
• Allocation Type: Multi-year Fund
• Research Field: Applied pharmacology
• Research Institution: Keio University
• Principal Investigator: KOSE Noriko 慶應義塾大学, 薬学部, 研究員 (60348612)
• Project Period (FY): 2011 – 2012
• Keywords: 薬物代謝酵素 / トランスポーター

Research Abstract

We analyzed the mechanisms of hypotaurine deficiency in the placenta of ezrin (Vil2) gene knockout mouse which shows fetal growth retardation. The results indicate that hypotaurine concentration in the placenta is mainly supplied by membrane transport

Research Products

• [Journal Article] Mechanism of nucleoside uptake in rat placenta and induction of placental CNT2 in experimental diabetes. (2012)
  • Author(s): Nishimura T, Chishu T, Tomi M, Nakamura R, Sato K, Kose N, Sai Y, Nakashima E
  • Journal Title: Drug Metab Pharmacokinet Volume: 27(4) Pages: 439-46
• [Journal Article] Enhancement of zidovudine transfer to molt-4 cells, a human t-cell model, by dehydroepiandrosterone sulfate. (2011)
  • Author(s): Nishimura T, Tanaka J, Tomi M, Seki Y, Kose N, Sai Y, Nakashima E
  • Journal Title: J Pharm Sc Volume: 100(9) Pages: 3959-67
  • DOI: doi:10.1002/jps.22624
• [Presentation] (2012)
  • Author(s): Sugita Y, Higuchi K, Kamata K, Nishimura T, Kose N, Sai Y, Tomi M, Nakashima E
  • Organizer: International Symposium on Past, Present and Future of Molecular Pharmacokinetics
  • Place of Presentation: Tokyo Japan
  • Year and Date: 20120100
• [Presentation] (2012)
  • Author(s): Duereh M, Higuchi K, Nishimura T, Kose N, Tomi M, Nakashima E
  • Organizer: International Symposium on Past, Present and Future of Molecular Pharmacokinetics
  • Place of Presentation: Tokyo Japan
  • Year and Date: 20120100
• [Presentation] (2011)
  • Author(s): Sugita Y, Higuchi K, Kamata K, Nishimura T, Kose N, Sai Y, Tomi M, Nakashima E
  • Organizer: Asian Federation for Pharmaceutical Sciences 2011
  • Place of Presentation: Kuala Lumpur Malaysia
  • Year and Date: 20111200
• [Presentation] (2011)
  • Author(s): Oda K, Nishimura T, Kose N, Tomi M, Nakashima E
  • Organizer: Asian Federation for Pharmaceutical Sciences 2011
  • Place of Presentation: Kuala Lumpur Malaysia
  • Year and Date: 20111200
• [Presentation] (2011)
  • Author(s): Duereh M, Nishimura T, Sugita Y, Kose N, Tomi M, Nakashima E
  • Organizer: Asian Federation for Pharmaceutical Sciences 2011
  • Place of Presentation: Kuala Lumpur Malaysia
  • Year and Date: 20111200
• [Presentation] (2011)
  • Author(s): Asada T, Takanohashi T, Nishimura T, Kose N, Tomi M, Nakashima E.
  • Organizer: 26th JSSX Annual Meeting
  • Place of Presentation: Hiroshima Japan
  • Year and Date: 20111100
• [Presentation] (2011)
  • Author(s): Mariam Duereh、西村友宏、巨勢典子、登美斉俊、中島恵美
  • Organizer: 第55回日本薬学会関東支部大会
  • Place of Presentation: 船橋
  • Year and Date: 20111000
• [Presentation] (2011)
  • Author(s): 杉田友紀, 鎌田可奈子, 西村友宏, 巨勢典子, 崔 吉道, 登美斉俊, 中島恵美
  • Organizer: 第6回トランスポーター研究会年仙台
  • Place of Presentation: 仙台
  • Year and Date: 20110600
• [Presentation] (2011)
  • Author(s): 小田憲司, 西村友宏, 巨勢典子, 登美斉俊, 中島恵美
  • Organizer: 第6回トランスポーター研究会年会
  • Place of Presentation: 仙台
  • Year and Date: 20110600
• [Presentation] (2011)
  • Author(s): 西村友宏, 田中純, 登美斉俊, 巨勢典子, 中島恵美
  • Organizer: 日本薬剤学会第26年会
  • Place of Presentation: 東京
  • Year and Date: 20110500
• [Presentation] (2011)
  • Author(s): 小田憲司, 西村友宏, 巨勢典子, 登美斉俊, 中島恵美
  • Organizer: 日本薬剤学会第26年会
  • Place of Presentation: 東京
  • Year and Date: 20110500