Analysis of the mechanisms for the bladder pain in interstitial cystitis: the role of substance P and hydrogen sulfide

2014 Fiscal Year Final Research Report

• Project/Area Number: 23790609
• Research Category: Grant-in-Aid for Young Scientists (B)
• Allocation Type: Multi-year Fund
• Research Field: Applied pharmacology
• Research Institution: Kinki University
• Principal Investigator: TSUBOTA Maho 近畿大学, 薬学部, 助教 (90510123)
• Project Period (FY): 2011-04-28 – 2015-03-31
• Keywords: 間質性膀胱炎 / 硫化水素 / サブスタンスP / Cav3.2

Outline of Final Research Achievements

This study clarified that, in the bladder tissues, substance P (SP) upregulates cystathione-γ-lyase (CSE) via NK1, and endogenous hydrogen sulfide generated by SP/NK1/CSE pathway facilitates processing of inflammation and participates in the development and maintenance of bladder pain through the activation of Cav3.2. These results suggest that the drug targeting these signaling pathway appears to serve as novel therapeutic strategy for treatment of painful bladder diseases including interstitial cystitis.

Free Research Field

薬理学