2012 Fiscal Year Final Research Report
The analysis of novel neuropathic pain related protein in the mechanism of chronic pain.
| Project/Area Number |
23790651
|
|---|
| Research Category |
Grant-in-Aid for Young Scientists (B)
|
| Allocation Type | Multi-year Fund |
|---|
| Research Field |
Pain science
|
|---|
| Research Institution | Kansai Medical University |
|---|
Principal Investigator |
KATANO Tayo 関西医科大学, 医学部, 講師 (60469244)
|
|---|
| Project Period (FY) |
2011 – 2012
|
| Keywords | 疼痛の発生・増強機構 / プロテオミクス / コンディショナル KO |
|---|
| Research Abstract |
To clarify the role and functions of Neuropathic Pain RelatedProtein-A,-B (NPRP-A、NPRP-B) , we analyzed biological properties and pain responses after spared nerve injury (SNI) of NPRP-B using specific antibody and knock-out mice. NPRP-B is highly expressed in the central nervous system including spinal dorsal horn and especially enriched in synaptosomal fraction. NPRP-B exists as phosphorylated protein. In NPRP-B knock-out mice, mechanical allodynia is significantly reduced after SNIcompared with that in wild-type mice.
|
-
-
[Journal Article] Involvement of Tyr1472 phosphorylation of NMDA receptor NR2B subunit in postherpetic neuralgia in model mice2012
Author(s)
Unezaki S, Sasaki A, Mabuchi T, Matsumura S, Katano T, Nishio N, Andoh T, Nakazawa T, Yamamoto T, Nakatsuka T, Kuraishi Y and Ito S
-
Journal Title
Mol. Pain
Volume: 59(1-13)
Pages: 8
DOI
Peer Reviewed
-
-
-
-
-
-
-
-
-
