2013 Fiscal Year Final Research Report
Consideration of the strategy for prevention of cardiovascular disease from the perspective of fatty acid composition and catalytic enzyme.
| Project/Area Number |
23790656
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Multi-year Fund |
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| Research Field |
Hygiene
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| Research Institution | Gunma University |
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Principal Investigator |
MATSUI HIROKI 群馬大学, 保健学研究科, 助教 (20431710)
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| Project Period (FY) |
2011 – 2012
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| Keywords | 心血管病 / 遊離脂肪酸 / メタボリックシンドローム / 予防医学 / 触媒酵素 |
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| Research Abstract |
The clinical findings suggest that elevated plasma free fatty acids could be associated with acceleration of cardiovascular disease. However, little is known about the mechanism by which disturbance for the effect of fatty acid composition in heart or vessel results in cardiovascular diseases. We have focused on two fatty acid catalytic enzymes, Stearoyl-CoA desaturase 1 (SCD1), that catalyzes the synthesis of monounsaturated fatty acids (MUFA) from saturated fatty acids (SFA), Elongase of long chain fatty acids 6 (Elovl6), that catalyzes the elongation of long-chain SFA and MUFA. Collectively, our results suggest that perturbation of fatty acid composition in heart and blood vessel leads to the onset and development of cardiovascular disease, and also suggest that SCD1 and Elovl6 as the novel protective and therapeutic target for cardiovascular disease.
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