2012 Fiscal Year Final Research Report
Research on protection against influenza viral infection using human monoclonal antibody
| Project/Area Number |
23790660
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Multi-year Fund |
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| Research Field |
Hygiene
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| Research Institution | Osaka Prefecture University |
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Principal Investigator |
YASUGI Yasugi 大阪府立大学, 大学院・生命環境科学研究科, 助教 (40589008)
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| Project Period (FY) |
2011 – 2012
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| Keywords | インフルエンザウイルス / ヒト型抗体 |
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| Research Abstract |
Our established human monoclonal antibody (HuMAb) 5A7 recognized a highly conserved regionof hemagglutinin (HA) in influenza B viruses (FluB). 5A7 broadly neutralized FluB and showed significant therapeutic efficacy in mice. These results indicate that 5A7 provides insight for the development of a universal vaccine against FluB. Also we studied the diversity of A(H1N1)pdm09 using neutralizing HuMAb 5E4 recognizing antigenic site Sb in the HA protein of A(H1N1)pdm09. Neutralization titers were significantly reduced against 5E4 in the 2010/11 compared with the 2009/10 samples. Sequences in Sb were being positively selected between 2009/10 and 2010/11. Variants in the antigenic site Sb increased significantly worldwide from GenBank, indicating that the antigenic variants in Sb are likely to be in global circulation currently.
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[Presentation] 2009 pandemic influenza A(H1N1) viruses with D222G and Q223R hemagglutinin mutations exist as a minor population in human upper airways2011
Author(s)
Nakaya T, Yasugi M, Nakamura S, Daidoji T, Ramadhany R, Yang CS, Yasunaga T, Iida T, Horii T, Ikuta K, Takahashi K
Organizer
International Union of Microbiological Societies 2011 Congress
Place of Presentation
Sapporo
Year and Date
2011-09-13
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