2013 Fiscal Year Final Research Report
The study of in utero and prepubertal exposure of N-EtFOSE, persistent fluorinated chemical
| Project/Area Number |
23790676
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Multi-year Fund |
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| Research Field |
Hygiene
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| Research Institution | Suzuka University of Medical Science |
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Principal Investigator |
BAN SUSUMU 鈴鹿医療科学大学, 薬学部, 助手 (30399828)
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| Project Period (FY) |
2011 – 2013
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| Keywords | 環境中毒 / 内分泌かく乱物質 / 次世代影響 / 難分解性 |
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| Research Abstract |
N-EtFOSE (N-ethylperfluorooctane sulfonate amide ethanol) is one of the materials for PFOS synthesis, it is not well known about its influences. In this study, we conducted in utero and prepubertal exposures to N-EtFOSE. In utero N-EtFOSE exposure alters the placental gene expressions and the patterns of these gene expressions are different between males and females. Prepubertal exposures to N-EtFOSE resulted in the serum testosterone levels and the altering gene expressions involved in testosterone synthesis in male rats, and increasing rate of abnormal estrus cycles and the altering gene expressions involved in estrogen synthesis in female rats.
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