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2013 Fiscal Year Final Research Report

Study on the health effects of industrial chemical with potential hepatotoxicity

Research Project

  • PDF
Project/Area Number 23790681
Research Category

Grant-in-Aid for Young Scientists (B)

Allocation TypeMulti-year Fund
Research Field Hygiene
Research InstitutionNational Institute of Occupational Safety and Health, Japan

Principal Investigator

YANAGIBA Yukie  独立行政法人労働安全衛生総合研究所, 健康障害予防研究, 研究員 (90467283)

Project Period (FY) 2011 – 2013
KeywordsCYP2E1 / DMAC / 肝障害
Research Abstract

DMAC is widely used in pharmaceutical and industrial chemical compounds. The cyp2e1+/+and cyp2e1-/- mice were exposed to inhalation of DMAC or vehicle control (10, 25, 50 and 250ppm) for 14 days., In cyp2e1+/+ and cyp2e1-/-mice, plasma AST and ALT activities were significantly increased at 50 and 250ppm of DMAC. The histological changes were observed in both genotypes. In addition, focal necrosis and fatty degeneration was also observed in the cyp2e1-/- at the high concentration exposure. cyp2e1-/- were detected in the exposed group for NMAC and DMAC in mice urine. Further, NMAC and DMAC was high concentration as compared to cyp2e1+/+ mice. cyp2e1+/+ were detected in the exposed group for acetamide in mice urine. Hence, most of the DMAC metabolism takes place via CYP2E1, but it is indicated that there is a possibility that other pathways also exist.

  • Research Products

    (4 results)

All 2012

All Presentation (4 results)

  • [Presentation] Oxidative metabolism effects of inhalation exposure to dimethylacetamide2012

    • Organizer
      The 6^<th> International Congress of Asian Society of Toxicology
    • Place of Presentation
      仙台国際センター
    • Year and Date
      2012-07-20
  • [Presentation] ジメチルアセトアミド吸入ばく露による肝臓での酸化的代謝への影響について2012

    • Author(s)
      (柳場由絵)、須田恵、王瑞生、久保田久代、北條理恵子、那須民江
    • Organizer
      第39回日本毒性学会
    • Place of Presentation
      仙台国際センター
    • Year and Date
      2012-07-18
  • [Presentation] DMAC吸入曝露による肝臓における酸化ストレスの増加2012

    • Author(s)
      (柳場由絵)、須田恵、王瑞生、扇祖銓、久保田久代、北條理恵子、那須民江
    • Organizer
      第85回日本産業衛生学会
    • Place of Presentation
      名古屋国際会議場
    • Year and Date
      2012-06-01
  • [Presentation] ジメチルアセトアミド吸入曝露による肝臓における酸化ストレスの増加2012

    • Author(s)
      (柳場由絵)、須田恵、王瑞生、扇祖銓、久保田久代、北條理恵子、那須民江
    • Organizer
      第82回日本衛生学会
    • Place of Presentation
      京都大学
    • Year and Date
      2012-03-25

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Published: 2015-06-25  

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