2012 Fiscal Year Final Research Report
Role of orexinergic system in the mechanism underlying an antidepressant-like effect of kososan
| Project/Area Number |
23790751
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Multi-year Fund |
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| Research Field |
General internal medicine (including Psychosomatic medicine)
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| Research Institution | Kitasato University |
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Principal Investigator |
ITO Naoki 北里大学, 東洋医学総合研究所, 研究員 (00370164)
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| Research Collaborator |
HANAWA Toshihiko 北里大学, 東洋医学総合研究所, 所長 (40164892)
OIKAWA Tetsuro 北里大学, 東洋医学総合研究所, 部長 (10370165)
YAMADA Haruki 北里大学, 北里生命科学研究所, 教授 (60096691)
YABE Takeshi 北里大学, 北里生命科学研究所, 講師 (40239835)
NAGAI Takayuki 北里大学, 北里生命科学研究所, 講師 (00172487)
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| Project Period (FY) |
2011 – 2012
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| Keywords | 香蘇散 / 抗うつ様効果 / オレキシン / neuropeptide Y |
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| Research Abstract |
In the present study, we first found orexin A (OX-A) increases the production of neuropeptide Y (NPY) from hippocampal cultured cells. Also, our previous study has shown that an antidepressant-like effect of kososan is linked in some way to the regulation of OX-A and NPY. Thus, the present findings highlight the presence of a network between OX-A and NPY in the hippocampus. This may be useful for our understanding the mechanism underlying kososan’s antidepressant-like property.
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