2013 Fiscal Year Final Research Report
Steatohepatitis as altered immune metabolism by Regulatory T cell
| Project/Area Number |
23790791
|
|---|
| Research Category |
Grant-in-Aid for Young Scientists (B)
|
| Allocation Type | Multi-year Fund |
|---|
| Research Field |
Gastroenterology
|
|---|
| Research Institution | Osaka University |
|---|
Principal Investigator |
HAMAGUCHI Masahide 大阪大学, 免疫学フロンティア研究センター, 特任助教 (80350883)
|
|---|
| Project Period (FY) |
2011 – 2013
|
| Keywords | 非アルコール性脂肪肝炎 / 非アルコール性脂肪疾患 / 制御性T細胞 / 慢性炎症 / インスリン抵抗性 / レプチン抵抗性 |
|---|
| Research Abstract |
Chronic inflammation is now considered to have a pivotal role in the metabolic abnormality. In liver, steatohepatitis has been recognized as the hallmarks of chronic inflammation. However, the mechanisms underlying the progression from simple steatosis to steatohepatitis have not clarified yet. Here, we showed that immune supressive activity by Treg cells were impaired under high leptin condition and steatohepatitis was observed under the condition of temporally liver regulatory T (Treg) cells depletion combined with high fat diet (HFD). Taken together, altered immune metabolism by Regulatory T cell due to leptin resistance in subjects with over nutrition or obesity could be a pathogen for the development of Steatohepatitis.
|
