Analysis of the interferon lambda receptor expression as a Chronic hepatitis C therapy prediction factor

2013 Fiscal Year Final Research Report

• Project/Area Number: 23790801
• Research Category: Grant-in-Aid for Young Scientists (B)
• Allocation Type: Multi-year Fund
• Research Field: Gastroenterology
• Research Institution: Yokohama City University
• Principal Investigator: NOZAKI Akito 横浜市立大学, センター病院, 講師 (20335631)
• Project Period (FY): 2011 – 2013
• Keywords: Ｃ型慢性肝炎 / Ｃ型肝炎ウイルス（ＨＣＶ） / IL28B SNP

Research Abstract

In a retrospective study of 101 patients infected with either genotype 2a (n = 65) or 2b (n = 36) and treated with peginterferon plus ribavirin, we investigated predictive factors for a sustained virological response (SVR), including genetic variations near the IL28B gene and clinical variables such as age, gender, body mass index, stage of fibrosis, and drug adherence. Ultra-rapid virological response, rapid virological response (RVR), end-of-treatment response, SVR, and relapse rates were 22.2%, 61.4%, 95.0%, 87.1%, and 7.9%, respectively. In univariate analysis, RVR and IL28B single-nucleotide polymorphisms (SNPs) were significantly associated with SVR. In subgroup analysis, IL28B SNPs were significantly associated with SVR in genotype 2a patients but not in genotype 2b patients. In multiple logistic regression analysis, RVR and IL28B SNP (rs8099917) were independently associated with SVR. Furthermore, IL28B SNP was significantly associated with relapse but RVR was not.

Research Products

• [Journal Article] Effects of IL-28B gene polymorphism on response to peginterferon plus ribavirin combination therapy for genotype 2 chronic hepatitis C (2013)
  • Author(s): Shimoyama Y, Nozaki A(corresponding author), Morimoto M, Moriya S, Kondo M, Fukuda H, Numata K, Miyajima E, Oba MS, Taguri M, Morita S, Maeda S, Tanaka K
  • Journal Title: Hepatology Research Volume: 43(9) Pages: 919-924
  • Peer Reviewed
• [Journal Article] Fucosylated fraction of alpha-fetoprotein as a serological marker of early hepatocellular carcinoma (2013)
  • Author(s): Moriya S, Morimoto M, Numata K, Nozaki A, Shimoyama Y, Kondo M, Nakano M, Maeda S, Tanaka K
  • Journal Title: Anticancer Res Volume: 33(3) Pages: 997-1001
  • Peer Reviewed
• [Journal Article] Hepatic failure in pregnancy successfully treated by online hemodiafiltration : Chronic hepatitis B virus infection without viral genome mutation (2013)
  • Author(s): Arata S, Nozaki A, Takizawa K, Kondo M, Morimoto M, Numata K, Hayashi S, Watanabe T, Tanaka Y, Tanaka K
  • Journal Title: Hepatology Research Volume: 43(12) Pages: 1356-1360
  • Peer Reviewed
• [Presentation] 遺伝子検査をもっと身近に : チーム医療に根ざした院内における遺伝子検査体制の構築シナリオ (2013)
  • Author(s): 名野崎昭人
  • Organizer: 日本臨床検査自動化学会第45回大会ランチョンセミナー10
  • Place of Presentation: パシフィコ横浜(神奈川県横浜市)
  • Year and Date: 2013-10-12
  • Invited
• [Presentation] IL28B SNPはgenotype 2のC型慢性肝炎に対するPEG-IFN/RBV療法のSVR予測因子となりえるか? (2013)
  • Author(s): 名野崎昭人,下山友, 田中克明
  • Organizer: JDDW2013ワークショップ
  • Place of Presentation: 品川プリンスホテル(東京都品川区)
  • Year and Date: 2013-10-09
• [Presentation] Serotype 2型C型慢性肝炎に対するPEG-IFN/RBV併用療法の治療効果予測因子の検討 (2012)
  • Author(s): 下山友, 野﨑昭人, 清水悠朗, 滝澤憲一, 守屋聡, 近藤正晃, 福田浩之, 森本学, 沼田和司, 田中克明, 前田愼
  • Organizer: JDDW2012
  • Place of Presentation: 神戸国際展示場(兵庫県神戸市)
  • Year and Date: 2012-10-10
• [Presentation] 当センターにおけるPEG-IFNα2b+RBV併用療法におけるIL28B SNP解析の意義 (2011)
  • Author(s): 野﨑昭人, 森岡友, 田中克明, 木田沙緒里, 田中春華, 竹森美紀, 廣瀬春香, 米澤広美, 宮島栄治
  • Organizer: 日本臨床検査自動化学会第43回大会
  • Place of Presentation: パシフィコ横浜(神奈川県横浜市)
  • Year and Date: 2011-10-06
• [Patent(Industrial Property Rights)] C型肝炎治療剤 (2014)
  • Inventor(s): 野﨑昭人、田中克明、池田正徳、加藤宜之
  • Industrial Property Rights Holder: 公立法人横浜市立大学、国立大学法人 岡山大学
  • Industrial Property Rights Type: 特許
  • Industrial Property Number: 特許第5527549号
  • Acquisition Date: 2014-04-25
  • Overseas