2012 Fiscal Year Final Research Report
Characterization of LRRK2 in enteric nervous system
| Project/Area Number |
23790809
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Multi-year Fund |
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| Research Field |
Gastroenterology
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| Research Institution | Kitasato University |
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Principal Investigator |
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| Project Period (FY) |
2010 – 2012
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| Keywords | 食道 / 胃 / 十二指腸 |
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| Research Abstract |
In the present study, we demonstrated that (i) LRRK2 interacts with tau in a tubulin-dependent manner; (ii) LRRK2 directly phosphorylates tubulin-associated tau, but not free tau. Furthermore, we revealed that LRRK2 overexpressing cells exhibitedsignificantly shorter neurites than control cells. Our results suggest that LRRK2 plays an important role as a physiological regulator for phosphorylation-mediated dissociation of tau from microtubules, which is an integral aspect of microtubule dynamics essential for neurite outgrowth and axonal transport.
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