2012 Fiscal Year Final Research Report
The outside-in regulatory mechanisms of atherosclerosis
| Project/Area Number |
23790834
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Multi-year Fund |
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| Research Field |
Circulatory organs internal medicine
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| Research Institution | The University of Tokyo |
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Principal Investigator |
TANAKA Kimie 東京大学, 保健・健康推進本部, 助教 (30508065)
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| Project Period (FY) |
2011 – 2012
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| Keywords | 循環器・高血圧 / 動脈硬化 / 血管外膜 / vasa vasorum / 血管周囲組織 |
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| Research Abstract |
Exaggerate formation of vasa vasorum plays an important role in the pathogenesis of atherosclerosis. However, it remains unclear whether locally applied angiogenesis inhibitor decreases vasa vasorum formation and atherosclerotic lesion progression. In this study, an experiment using femoral arteries of old hypercholesterolemic mice showed that local administration of a growth factor inhibitor in adventitia inhibited adventitial angiogenesis and atherosclerotic lesion progression under hypercholesterolemia without mechanical vascular injury.
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