2012 Fiscal Year Final Research Report
The role of nuclear hormone receptor PPARδon the pathogenesis of diabetic nephropathy
| Project/Area Number |
23790942
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Multi-year Fund |
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| Research Field |
Kidney internal medicine
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| Research Institution | Okayama University |
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Principal Investigator |
OGAWA Daisuke 岡山大学, 大学院・医歯薬学総合研究科, 准教授 (70535195)
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| Project Period (FY) |
2011 – 2012
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| Keywords | 糖尿病性腎症 / 核内受容体 |
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| Research Abstract |
Activation of the nuclear hormone receptor peroxisome proliferator-activated receptor o(PPARo) has been shown to improve insulin resistance, adiposity, and plasma HDL levels. Recently, several studies reported that activation of PPARδis atheroprotective, however, the effect for the renalfunction remains unclear. Here we report the renoprotecitve effects of PPARo activation in a model of streptozotosin-induced diabetic nephropathy.
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[Journal Article] Vaspin is an adipokine ameliorating ER Stress in obesity as a ligand for cell-surface GRP78/MTJ-1 complex2012
Author(s)
Nakatsuka A, Wada J, Iseda I, Teshigawara S, Higashio K, Murakami K, Kanzaki M, Inoue K, Terami T, Katayama A, Hida K, Eguchi J, Horiguchi CS, Ogawa D, Matsuki Y, Hiramatsu R, Yagita H, Kakuta S, Iwakura Y, Makino H
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Journal Title
Diabetes
Volume: 61
Pages: 2823-2832
Peer Reviewed
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Author(s)
Miyamoto S, Shikata K, Miyasaka K, Okada S, Sasaki M, Kodera R, Hirota D, Kajitani N, Takatsuka T, Kataoka HU, Nishishita S, Sato C, Funakoshi A, Nishimori H, Uchida HA, Ogawa D, Makino H
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Journal Title
Diabetes
Volume: 61
Pages: 897-907
Peer Reviewed
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[Journal Article] RXR antagonism induces G0/G1 cell cycle arrest and ameliorates obesity by up-regulating the p53-p21 (Clip1) pathway in adipocytes2012
Author(s)
Nakatsuka A, Wada J, Hida K, Hida A, Eguchi J, Teshigawara S, Murakami K, Kanzaki M, Inoue K, Terami T, Katayama A, Ogawa D, Kagechika H, Makino H
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Journal Title
J Pathol
Volume: 226
Pages: 784-95
Peer Reviewed
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[Journal Article] High glucose increases metallothionein expression in renal proximal tubular epithelial cells2011
Author(s)
Ogawa D, Asanuma M, Miyazaki I, Tachibana H, Wada J, Sogawa N, Sugaya T, Kitamura S, Maeshima Y, Shikata K, Makino H
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Journal Title
Exp Diabetes Res2011
Volume: 2011
Pages: 534872
Peer Reviewed
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