2013 Fiscal Year Final Research Report
Renal thrombotic microangiopathy associated with chronic GVHD after allogeneic hematopoietic stem cell transplantation
| Project/Area Number |
23790963
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Multi-year Fund |
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| Research Field |
Kidney internal medicine
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| Research Institution | Nippon Medical School |
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Principal Investigator |
MII Akiko 日本医科大学, 医学部, 助教 (50544417)
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| Project Period (FY) |
2011 – 2013
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| Keywords | 移植・再生医療 / 病理学 / 免疫学 |
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| Research Abstract |
Thrombotic microangiopathy (TMA) is one of the major complications after hematopoietic stem cell transplantation (HSCT). The pathogenesis of HSCT-associated TMA is controversial. We reported the cases of renal TMA involved in chronic graft versus host disease (GVHD). The pathologic features showed severe endothelial injury with glomerular and peritubular capillary C4d deposition, and we termed it chronic humoral GVHD. Moreover we created the rat renal GVHD model with pathologic TMA. We indicate that kidney is one of the target organs of GVHD associated with the development of TMA after HSCT.
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[Journal Article] Renal thrombotic microangiopathy associated with chronic humoral graft versus host disease after hematopoietic stem cell transplantation2011
Author(s)
Mii A, Shimizu A, Masuda Y, Fujino T, Kaneko T, Utsumi K, Arai T, Ishikawa A, Wakamatsu K, Tajika K, Iino Y, Katayama Y, Fukuda Y
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Journal Title
Pathol Int
Volume: 61
Pages: 34-41
DOI
Peer Reviewed
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[Journal Article] Renal thrombotic microangiopathy associated with chronic graft-versus-host disease after allogeneic hematopoietic stem cell transplantation2011
Author(s)
Mii A, Shimizu A, Kaneko T, Fujita E, Fukui M, Fujino T, Utsumi K, Yamaguchi H, Tajika K, Tsuchiya S, Iino Y, Katayama Y, Fukuda Y
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Journal Title
Pathol Int
Volume: 61
Pages: 518-27
DOI
Peer Reviewed
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