2013 Fiscal Year Final Research Report
The induction of anti-inflammatory macrophage for clinical approaches to adoptive transfer for kidney disease
| Project/Area Number |
23790964
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Multi-year Fund |
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| Research Field |
Kidney internal medicine
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| Research Institution | Nippon Medical School |
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Principal Investigator |
FUJITA EMIKO 日本医科大学, 医学部, 助教 (70600617)
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| Project Period (FY) |
2011 – 2013
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| Keywords | 糸球体腎炎 / マクロファージ / 炎症細胞 / 炎症 / 腎臓 / 病理学 |
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| Research Abstract |
The Aim of this study is to investigate the induction of anti-inflammatory macrophages in experimental nephritis and to verify its potential use in nephritis therapy. We research for molecular biological characteristics of inducted anti-inflammatory macrophages in vitro, and then verify that adoptive transfer of these macrophages might have effectiveness in experimental nephritis. In human glomerulonephritis, we assess that macrophage phenotype might have relevance to disease activity and confirm that the importance of to evaluate the macrophage phenotype when making histological decisions about renal biopsy histology.
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[Journal Article] 原著 : Proliferative glomerulonephritis with monoclonal immunoglobulin G3κdeposits in association with parvovirus B19 infection2012
Author(s)
Fujita E, Shimizu A, Kaneko T, Masuda Y, Ishihara C, Mii A, Higo S, Kajimoto Y, Kanzaki G, Nagasaka S, Iino Y, Katayama Y, Fukuda Y
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Journal Title
Hum Pathol
Volume: 43(12)
Pages: 2326-33
Peer Reviewed
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