2012 Fiscal Year Final Research Report
Elucidation of the lung and kidney cross-talk in acute kidney injury(AKI) and evaluation of urinary midkine as a diagnostic marker of AKI.
| Project/Area Number |
23790967
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Multi-year Fund |
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| Research Field |
Kidney internal medicine
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| Research Institution | Fujita Health University |
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Principal Investigator |
HAYASHI Hiroki 藤田保健衛生大学, 医学部, 助教 (10378086)
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| Research Collaborator |
YUZAWA Yukio 藤田保健衛生大学, 医学部, 教授 (00191479)
MARUYAMA Shoichi 名古屋大学, 大学院医学研究科, 准教授 (10362253)
NISHIMURA Kunihiro 独立行政法人国立循環器病研究センター, 室長 (70397834)
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| Project Period (FY) |
2011 – 2012
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| Keywords | 腎臓学 |
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| Research Abstract |
We have retrospectively studied a cohort of 2579 patients admitted to the intensive care unit. The total AKI prevalence was 30% according to the AKIN criteria and after adjustment for covariates, AKIN stages remained independently associated with in-hospital mortality. An observational, retrospective analysis has been performed for 52 ALI/ARDS patients controlled by the noninvasive positive pressure ventilation (NPPV). Various cytokine levels were elevated in bronchoalveolar lavage from ALI/ARDS patients who developed AKI. These biomarkers were sensitive predictor of the NPPV failures. These findings strongly suggested the organ cross-talk between kidney and lung in ALI/ARDS. Finally we have confirmed the potential of urinary midkine as a novel biomarker for the early detection of AKI.
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