2012 Fiscal Year Final Research Report
Investigation into the pathogenesis of refractory neuropathies focusing on axon-myelin interaction.
| Project/Area Number |
23790987
|
|---|
| Research Category |
Grant-in-Aid for Young Scientists (B)
|
| Allocation Type | Multi-year Fund |
|---|
| Research Field |
Neurology
|
|---|
| Research Institution | Nagoya University |
|---|
Principal Investigator |
IIJIMA Masahiro 名古屋大学, 大学院・医学系研究科, COE 特任助教 (40437041)
|
|---|
| Project Period (FY) |
2011 – 2012
|
| Keywords | 難治性ニューロパチー / 軸索-髄鞘間相互作用 / transient axoglial glycoprotein-1 (TAG-1) / 脱髄 / 軸索障害 |
|---|
| Research Abstract |
Axonal damage concomitant of inflammatory demyelination is one of the major factors for refractory or therapy-resistant peripheral neuropathies. In this study, we focused into transient axoglial glycoprotein-1 (TAG-1) which is related to axon-myelin interaction. We induced experimental autoimmune neuritis (EAN) on TAG-1 knockout (KO) mice and investigated phenotypes by clinicoelectrophysiological, and pathological analysis. As a result, the breakdown of the axon-myelin interaction could be associated to vulnerability of axonal function as well as refractory characteristics in inflammatory demyelinating neuropathies.
|
-
[Journal Article] Autonomic manifestations in acute sensory ataxic neuropathy: A case report2013
Author(s)
Ohyama K, Koike H, Masuda M, Sone J, Hashimoto R, Tomita M, Kawagashira Y, Iijima M, Nakamura T, Watanabe H, Sobue G.
-
Journal Title
-
-
-
-
-
[Journal Article] Differential, size-dependent sensory neuron involvement in the painful and ataxic forms of primary Sjogren's syndrome-associated neuropathy.2012
Author(s)
Kawagashira Y, Koike H, Fujioka Y, Hashimoto R, Tomita M, Morozumi S, Iijima M, Katsuno M, Tanaka F, Sobue G
-
Journal Title
J Neurol Sci.
Volume: 319
Pages: 139-46
Peer Reviewed
-
-
-
[Journal Article] The spectrum of clinicopathological features in pure autonomic neuropathy2012
Author(s)
Koike H, Hashimoto R, Tomita M, Kawagashira Y, Iijima M, Koyano S, Momoo T, Yuasa H, Mitake S, Higashihara M, Kaida K, Yamamoto D, Hisahara S, Shimohama S, Nakae Y, Johkura K, Vernino S, Sobue G.
-
Journal Title
J Neurol.
Volume: 259
Pages: 2067-75
Peer Reviewed
-
-
-
[Journal Article] The spectrum of clinicopathological features in pure autonomic neuropathy.2012
Author(s)
Koike H, Hashimoto R, Tomita M, Kawagashira Y, Iijima M, Koyano S, Momoo T, Yuasa H, Mitake S, Higashihara M, Kaida K, Yamamoto D, Hisahara S,Shimohama S, Nakae Y, Johkura K, Vernino S, Sobue G.
-
Journal Title
J Neurol
Volume: 259(10)
Pages: 2067-75
Peer Reviewed
-
[Journal Article] Natural history of transthyretin Val30Met familial amyloid polyneuropathy: analysis of late-onset cases from non-endemic areas2012
Author(s)
Koike H, Tanaka F, Hashimoto R, Tomita M, Kawagashira Y, Iijima M, Fujitake J, Kawanami T, Kato T, Yamamoto M, Sobue G.
-
Journal Title
J Neurol Neurosurg Psychiatry
Volume: 83(2)
Pages: 152-8
Peer Reviewed
-
-
-
-
-
-
-
-
[Journal Article] Systemic but asymptomatic transthyretin amyloidosis 8 years after domino liver transplantation.2011
Author(s)
Koike H, Kiuchi T, Iijima M, Ueda M, Ando Y, Morozumi S, Tomita M, Kawagashira Y, Watanabe H, Katsuno M, Shimoyama Y, Okazaki Y, Kamei H, Sobue G.
-
Journal Title
J Neurol Neurosurg Psychiatry
Volume: 82(11)
Pages: 1287-90
Peer Reviewed
-
-
-
-
-
-
-
-
-
