2013 Fiscal Year Final Research Report
Establishment of the mesureing system for early diagnosis of Alzheimer's disease using blood biological markers.
| Project/Area Number |
23790990
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Multi-year Fund |
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| Research Field |
Neurology
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| Research Institution | Tottori University |
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Principal Investigator |
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| Project Period (FY) |
2011 – 2013
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| Keywords | 神経分子病態学 / アルツハイマー型認知症 / 糖鎖 / 診断マーカー / 脳神経疾患 |
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| Research Abstract |
The purpose of this study was to purify two glycoproteins, which is altered in Alzheimer's disease (AD) serum, analyze the region changed in AD, and then establish the measuring system. However, we had the problems during the steps of purify them, for example another sugar chains contaminated in the target glycoproteins. Although we cannot progress analysis, we finally decided the most suitable way to purify the proteins and are now advancing as the first planning. And we found the both content and the activity of serum sialyltransferase (STase) which attach the sialic acid to the transferrin are lower in Alzheimer's serum. This indicates one of the causes about altered sialic acid in AD.
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Research Products
(29 results)
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[Journal Article] Japanese Alzheimer's Disease Neuroimaging Initiative. Multipleγ-secretase product peptides are coordinately increased in concentration in the cerebrospinal fluid of a subpopulation of sporadic Alzheimer's disease subjects2012
Author(s)
Hata S, Taniguchi M, Piao Y, Ikeuchi T, Fagan AM, Holtzman DM, Bateman R, Sohrabi HR, Martins RN, Gandy S, Urakami K, Suzuki T
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Journal Title
Mol Neurodegener
Volume: 16
DOI
Peer Reviewed
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