2013 Fiscal Year Final Research Report
Analyses for transport of Amyloid beta through the blood-brain barrier
| Project/Area Number |
23790994
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Multi-year Fund |
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| Research Field |
Neurology
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| Research Institution | Yamaguchi University |
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Principal Investigator |
SANO Yasuteru 山口大学, 医学(系)研究科(研究院), 助教 (20379978)
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| Project Period (FY) |
2011 – 2013
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| Keywords | アミロイドβ / 血液脳関門 |
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| Research Abstract |
The clearance of amyloid beta (Ab) from the brain could be a novel therapeutic target for Alzheimer disease. We examined the role of efflux transporters as well as LRP1 on Ab transport on human BBB. Our results using a new human in vitro blood-brain barrier (BBB) model suggest that ABCG2 as well as LRP1 act to prevent the blood-borne Ab from entering brain at the human BBB. In addition, we also elucidated that rifampicin up-regulates the expression of LRP1 and ABCG2 in endothelial cells derived from human BBB.
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[Journal Article] O sera down-regulate AQP4 in human astrocyte and induce cytotoxicity independent of complement2013
Author(s)
Haruki H, Sano Y, Shimizu F, Omoto M, Tasaki A, Oishi M, Koga M, Saito K, Takahashi T, Nakada T, Kanda T
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Journal Title
Neurol Sci
Volume: 331(1-2)
Pages: 136-44
DOI
Peer Reviewed
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[Journal Article] Kanda Blood-brain barrier destruction determines Fisher/Bickerstaff clinical phenotypes : an in vitro study2013
Author(s)
Saito K, Shimizu F, Koga M, Sano Y, Tasaki A, Abe M, Haruki H, Maeda T, Suzuki S, Kusunoki S, Mizusawa H
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Journal Title
Neurol Neurosurg Psychiatry
Volume: 84(7)
Pages: 756-65
DOI
Peer Reviewed
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[Journal Article] Sequential changes in the non-coding control region sequences of JC polyomaviruses from the cerebrospinal fluid of patients with progressive multifocal leukoencephalopathy2013
Author(s)
Nakamichi K, Kishida S, Tanaka K, Suganuma A, Sano Y, Sano H, Kanda T, Maeda N, Kira J, Itoh A, Kato N, Tomimoto H, Kurane I, Lim CK, Mizusawa H, Saijo M
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Journal Title
Arch Virol
Volume: 158(3)
Pages: 639-50
DOI
Peer Reviewed
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[Journal Article] Establishment and characterization of human peripheral nerve microvascular endothelial cell lines : a new in vitro blood-nerve barrier (BNB) model2012
Author(s)
Abe M, Sano Y, Maeda T, Shimizu F, Kashiwamura Y, Haruki H, Saito K, Tasaki A, Kawai M, Terasaki T, Kanda T
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Journal Title
Cell Struct Funct
Volume: 37(2)
Pages: 89-100
URL
Peer Reviewed
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[Journal Article] p.Arg332Cys mutation of NOTCH3 gene in two unrelated Japanese families with CADASIL2011
Author(s)
Sano Y, Shimizu F, Kawai M, Omoto M, Negoro K, Kurokawa T, Fujisawa H, Suzuki M, Okayama N, Suehiro Y, Hinoda Y, Kanda T
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Journal Title
Intern Med
Volume: 50(22)
Pages: 2833-8
URL
Peer Reviewed
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