2012 Fiscal Year Final Research Report
Treatment for central nervous system demyelinating disorder using mesenchymal cell-derived Schwann cells
Project/Area Number |
23790996
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Research Category |
Grant-in-Aid for Young Scientists (B)
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Allocation Type | Multi-year Fund |
Research Field |
Neurology
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Research Institution | Kyushu University |
Principal Investigator |
MATSUSE Dai 九州大学, 医学研究院, 助教 (70596395)
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Research Collaborator |
OGATA Hidenori 九州大学, 医学系学府, 大学院生
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Project Period (FY) |
2011 – 2012
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Keywords | 細胞移植治療 / 間葉系細胞 / シュワン細胞 / 中枢性脱髄疾患 |
Research Abstract |
At first, we developed chronic experimental autoimmune encephalomyelitis (EAE) model rat from DA rats. We also induced to differentiate Schwann cells (BM-SCs) from bone marrow-derived mesenchymal cells (MSCs) of DA rats by adding several trophic factors. After developing EAE, BM-SCs, MSCs, or PBS (vehicle) were injected intrathecally. In BM-SC-transplanted group, clinical score and body weight recovered compared with the other 2 groups. Although the expression of PSA-NCAM was decreased in BM-SCs, the engraftment of these cells was successful. This treatment can be a breakthrough therapyfor central nervous system demyelinating disorder such as multiple sclerosis.
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[Journal Article] Autologous mesenchymal stem cell-derived dopaminergic neurons function in parkinsonian macaques.2013
Author(s)
Hayashi T, Wakao S, Kitada M, Ose T, Watabe H, Kuroda Y, Mitsunaga K, Matsuse D, Shigemoto T, Ito A, Ikeda H, Fukuyama H, Onoe H, Tabata Y, Dezawa M.
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Journal Title
J Clin Invest
Volume: 123
Pages: 272-284
DOI
Peer Reviewed
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[Journal Article] Multilineage-differentiating stress-enduring (Muse) cells are a primary source of induced pluripotent stem cells in human fibroblasts2011
Author(s)
Wakao S, Kitada M, Kuroda Y, Shigemoto T, Matsuse D, Akashi H, Tanimura Y, Tsuchiyama K, Kikuchi T, Goda M, Nakahata T, Fujiyoshi Y, DezawaM.
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Journal Title
Proc Natl Acad Sci U S A
Volume: 108
Pages: 9875-9880
DOI
Peer Reviewed
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[Journal Article] Anti-neurofascin antibody in patients with combined central and peripheral demyelination
Author(s)
Kawamura N, Yamasaki R, Yonekawa T, Matsushita T, Kusunoki S, Nagayama S, Fukuda Y, Ogata H, Matsuse D, Murai H, Kira J.
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Journal Title
Neurology
Volume: (in press)
Peer Reviewed
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[Journal Article] Transplantation of bone marrow stromal cells-derived neural precursor cells ameliorates deficits in a rat model of complete spinal cord transection.
Author(s)
Aizawa-Kohama M, Endo T, Kitada M, Wakao S, Sumiyoshi A, Matsuse D, Kuroda Y, Morita T, Jorge J. Riera, Kawashima R, Tominaga T, Dezawa M
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Journal Title
Cell Transplant
Volume: (in press)
DOI
Peer Reviewed
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