2012 Fiscal Year Final Research Report
Role of hepatic amino acid metabolism on the development of metabolic syndrome
| Project/Area Number |
23791011
|
|---|
| Research Category |
Grant-in-Aid for Young Scientists (B)
|
| Allocation Type | Multi-year Fund |
|---|
| Research Field |
Metabolomics
|
|---|
| Research Institution | Tohoku University |
|---|
Principal Investigator |
UNO Kenji 東北大学, 病院, 助教 (50596632)
|
|---|
| Project Period (FY) |
2011 – 2012
|
| Keywords | アミノ酸代謝 / メタボリックシンドローム / 肥満 / mTOR |
|---|
| Research Abstract |
Metabolism in different tissues/organs is regulated via both neuronal and humoral factors. We have previously demonstrated that neuronal networks, especially from the liver, play important roles in maintaining metabolic homeostasis among organs/tissues, including adipose tissue and pancreatic islets. Nutrient (carbohydrate, fat, and protein) overloads due to overeating affect these regulational systems, resulting in progression of metabolic disorders. In this study, we purpose to identify a new role of hepatic amino acid metabolismon the development of metabolic syndrome.
|
-
[Journal Article] Chronic mild stress alters circadian expressions of molecular clock genes in the liver2013
Author(s)
Kei Takahashi, Tetsuya Yamada, Sohei Tsukita, Keizo Kaneko, Yuta Shirai, Yuichiro Munakata, Yasushi Ishigaki, Junta Imai, Kenji Uno, Yutaka Hasegawa, Shojiro Sawada, Yoshitomo Oka, Hideki Katagiri
-
Journal Title
Am J Physiol Endocrinol Metab
Volume: 304
Pages: E301-9
DOI
Peer Reviewed
-
[Journal Article] Importance of endothelial NF-κB signalling in vascular remodelling and aortic aneurysm formation2013
Author(s)
Tokuo Saito, Yutaka Hasegawa, Yasushi Ishigaki, Tetsuya Yamada, Junhong Gao, Junta Imai, Kenji Uno, Keizo Kaneko, Takehide Ogihara, Tatsuo Shimosawa,Tomoichiro Asano, Toshiro Fujita, Yoshitomo Oka, Hideki Katagiri
-
Journal Title
Cardiovasc Res
Volume: 97
Pages: 106-14
DOI
Peer Reviewed
-
[Journal Article] Hepatic glucokinase modulates obesity predisposition by regulating BAT thermogenesis via neural signals2012
Author(s)
Sohei Tsukita, Tetsuya Yamada, Kenji Uno, Kei Takahashi, Keizo Kaneko, Yasushi Ishigaki, Junta Imai, Yutaka Hasegawa, Shojiro Sawada, Hisamitsu Ishihara, Yoshitomo Oka, Hideki Katagiri
-
Journal Title
Cell Metab
Volume: 16
Pages: 825-32
DOI
Peer Reviewed
-
[Journal Article] Hepatic peroxisome proliferator activated receptor-γ-fat-specific protein 27 pathway contributes to obesity-related hypertension via afferent vagal signals2012
Author(s)
Kenji Uno, Tetsuya Yamada, Yasushi Ishigaki, Junta Imai, Yutaka Hasegawa, Junhong Gao, Keizo Kaneko, Kimihiko Matsusue, Tomomi Yamazaki, Yoshitomo Oka, Hideki Katagiri
-
Journal Title
Eur Heart J
Volume: 33
Pages: 1279-89
DOI
Peer Reviewed
-
[Journal Article] Blockade of the nuclear factor-κB pathway in the endothelium prevents insulin resistance and prolongs life spans2012
Author(s)
Yutaka Hasegawa, Tokuo Saito, Takehide Ogihara, Yasushi Ishigaki, Tetsuya Yamada, Junta Imai, Kenji Uno, Junhong Gao, Keizo Kaneko, Tatsuo Shimosawa, Tomoichiro Asano, Toshiro Fujita, Yoshitomo Oka, Hideki Katagiri
-
Journal Title
Circulation
Volume: 125
Pages: 1122-33
DOI
Peer Reviewed
-
-
[Journal Article] Involvement of endoplasmic stress protein C/EBP homologous protein in arteriosclerosis acceleration with augmented biological stress responses2011
Author(s)
Junhong Gao, Yasushi Ishigaki, Tetsuya Yamada, Keiichi Kondo, Suguru Yamaguchi, Junta Imai, Kenji Uno, Yutaka Hasegawa, Shojiro Sawada, Hisamitsu Ishihara, Seiichi Oyadomari, Masataka Mori, Yoshitomo Oka, and Hideki Katagiri
-
Journal Title
Circulation
Volume: 124
Pages: 830-9
DOI
Peer Reviewed
-
-
-
-
-
-
-
-
-
-
-
-
-
