2012 Fiscal Year Final Research Report
The elucidation of physiological functions of transcription factor FoxO1 in pancreatic alpha cell
| Project/Area Number |
23791013
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Multi-year Fund |
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| Research Field |
Metabolomics
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| Research Institution | Gunma University |
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Principal Investigator |
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| Project Period (FY) |
2011 – 2012
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| Keywords | 糖尿病 / 膵臓 / α細胞 / グルカゴン / FoxO1 |
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| Research Abstract |
To elucidate the physiological roles of FoxO1 in pancreatic alpha cell, we prepared and analyzed the character of alpha cell-specific constitutive active-FoxO1 knockin mice (alpha-FoxO1-KI). Alpha-FoxO1 KI mice showed significant increases in plasma glucagon and blood glucose levels under random fed condition. We conclude that FoxO1 promotes glucagon secretion from pancreatic alpha cell.
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