2012 Fiscal Year Final Research Report
Roles of a novel lepin-induced transcript in the regulation of obesity and leptin resistance.
| Project/Area Number |
23791042
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Multi-year Fund |
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| Research Field |
Metabolomics
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| Research Institution | Wakayama Medical University |
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Principal Investigator |
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| Project Period (FY) |
2011 – 2012
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| Keywords | レプチン / 視床下部 / 摂食調節 / 肥満 / 糖尿病 |
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| Research Abstract |
In both normal and high-fat diet conditions, the body weights were decreased in LIT2-deficient mice compared to those in WT mice, although there were no changes in food intake between WT and LIT2-deficient mice. In addition, glucose tolerance and insulin sensitivity were increased in LIT2-deficient mice compared to those in WT mice. These results suggest that LIT2 regulates the actions of leptin such as energy expenditure and glucose metabolism rather than food intake in the hypothalamus.
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