2012 Fiscal Year Final Research Report
Investigation of the novel biological role of neuromedin S
| Project/Area Number |
23791065
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Multi-year Fund |
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| Research Field |
Endocrinology
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| Research Institution | National Cardiovascular Center Research Institute |
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Principal Investigator |
MORI Miwa 独立行政法人国立循環器病研究センター, 研究所, 特任研究員 (50363148)
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| Project Period (FY) |
2011 – 2012
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| Keywords | 内分泌 / 神経ペプチド / 生理活性ペプチド / ニューロメジンS |
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| Research Abstract |
The regional distribution of neuromedin S (NMS) in the rat brain was investigated using a highly sensitive radioimmunoassay. A high content of NMS peptide was found in the hypothalamus, midbrain, and pons-medulla oblongata, whereas abundant expression of NMS mRNA was detected only in the hypothalamus. These differing distributions of the mRNA and peptide suggest that nerve fibers originating from hypothalamic NMS neurons project into the brainstem. These results suggest novel, unknown physiological roles of NMS within the brainstem.
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