2012 Fiscal Year Final Research Report
Analysis of Hes1 mediated development and maintenance of leukemic stem cells for myeloid leukemia
| Project/Area Number |
23791068
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Multi-year Fund |
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| Research Field |
Hematology
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| Research Institution | University of Tsukuba |
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Principal Investigator |
SAKATA Mamiko (YANAGIMOTO Mamiko) 筑波大学, 筑波大学, 講師 (80451805)
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| Research Collaborator |
CHIBA Shigeru 筑波大学, 医学医療系, 教授 (60212049)
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| Project Period (FY) |
2011 – 2012
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| Keywords | 急性骨髄性白血病 / Notch / Hes1 / 腫瘍抑制 / サイトカイン受容体 |
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| Research Abstract |
We clarified the novel tumor suppressive roles of Hes1 in acute myeloid leukemia. Themechanism was downregulation of cytokine signaling by transcriptional repression of cytokine receptor by Hes1. Growth rate of Hes1-null leukemic cells was higher than that of control cells, which was abrogated by specific inhibitor for cytokine signaling. These data provide a novel insight into a target therapy for myeloid leukemia.
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[Journal Article] Identification of unbalanced genome copy number abnormalities in patients with multiple myeloma by single-nucleotide polymorphism genotyping microarray analysis2012
Author(s)
Kamada Y, Sakata-Yanagimoto M, Sanada M, Sato-Otsubo A, Enami T, Suzukawa K, Kurita N, Nishikii H, Yokoyama Y, Okoshi Y, Hasegawa Y, Ogawa S, Chiba S
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Journal Title
Int J Hematol
Volume: 96 (4)
Pages: 492-500
DOI
Peer Reviewed
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[Journal Article] Early Pathologic findings of bronchiolitis obliterans after allogeneic hematopoietic stem cell transplantations: a proposal from a case2012
Author(s)
Matsubara-Nakamoto R, Nishikii H, Yamada K, Ito M, Hasegawa Y, Kurita N, Obara N, Okoshi Y, Suzukawa K, Yokoyama Y, Sakata-Yanagimoto M, Noguchi M, Chiba S
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Journal Title
Case Report Hematol
Volume: 2012
Pages: 957612
DOI
Peer Reviewed
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[Journal Article] Treatment outcome of adult Burkitt lymphoma in Japanese patients with modified LMB protocol : a single center retrospective analysis2011
Author(s)
Nishikii H, Nakamura N, Kondo Y, Okoshi Y, Suzukawa K, Hasegawa Y, Yokoyama Y, Sakata-Yanagimoto M, Enami T, Noguchi M, Chiba S
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Journal Title
J Clin Exp Hematop
Volume: 51(2)
Pages: 109-114
Peer Reviewed
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[Journal Article] Frequent pathway mutations of splicing machinery in myelodysplasia2011
Author(s)
Yoshida K, Sanada M, Shiraishi Y, Nowak D, Nagata Y, Yamamoto R, Sato Y, Sato-Otsubo A, Kon A, Nagasaki M, Chalkidis G, Suzuki Y, Shiosaka M, Kawahata R, Yamaguchi T, Otsu M, Obara N, Sakata-Yanagimoto M, Ishiyama K, Mori H, Nolte F, Hofmann WK, Miyawaki
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Journal Title
Nature
Volume: 478(7367)
Pages: 64-69
DOI
Peer Reviewed
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[Journal Article] Neutrilizatino of the γ-secretase activity by monoclonal antibody against extracellular domain of niscastrin2011
Author(s)
Hayashi I, Takatori S, Urano Y, Miyake Y, Takagi J, Sakata-Yanagimoto M, Iwanari H, Osawa S, Morohashi Y, Li T, Wong PC, Chiba S, Kodama T, Hamakubo T, Tomita T, Iwatsubo T
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Journal Title
Oncogene. 9
Volume: 31(6)
Pages: 787-798
DOI
Peer Reviewed
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