2013 Fiscal Year Final Research Report
Interaction between monocytes and bone marrow microenvironment in pathogenesis of multiple myeloma
| Project/Area Number |
23791084
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Multi-year Fund |
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| Research Field |
Hematology
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| Research Institution | Sapporo Medical University |
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Principal Investigator |
IKEDA HIROSHI 札幌医科大学, 道民医療推進学講座, 特任助教 (60570132)
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| Project Period (FY) |
2011 – 2012
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| Keywords | 多発性骨髄腫 / 骨髄微小環境 / 単球 |
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| Research Abstract |
In this study, we examined the role of monocyte, a component of bone marrow microenvironment, in the MM progression. We investigated the proliferation of MM cell lines cultured alone or co-cultured with BMSCs and/or monocytes of MM patients. Consistently, we observed increased proliferation of MM cell lines in the presence of either BMSCs or monocytes compared to cell line-only control. Furthermore, the co-culture of BMSCs plus monocytes induced the greatest degree of proliferation of myeloma cells. In addition to increased proliferation, BMSCs and monocytes decreased the rate of apoptosis of myeloma cells. Our results therefore suggest that highlights the role of monocyte as an important component of the bone marrow microenvironment.
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Research Products
(5 results)
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[Journal Article] Genomic vulnerability to LINE-1 hypomethylation is a potential determinant of the clinicogenetic features of multiple myeloma2013
Author(s)
Nojima M, Suzuki H, Yasui H, Maruyama R, Yamamoto E, Ashida M, Itagaki M, Asaoku H, Ikeda H, Hayashi T, Imai K, Mori M, Tokino T, Ishida T, Toyota M, Shinomura Y
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Journal Title
Genome Medicine
Volume: 2013年10月号
Pages: 88-
Peer Reviewed
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