2012 Fiscal Year Final Research Report
The role of histone demethylase in chromosomal translocations : The dynamic modification of chromosomal structure
| Project/Area Number |
23791089
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Multi-year Fund |
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| Research Field |
Hematology
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| Research Institution | Jichi Medical University |
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Principal Investigator |
WADA Taeko 自治医科大学, 医学部, 助教 (30382956)
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| Project Period (FY) |
2011 – 2012
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| Keywords | 造血器腫瘍 / ヒストン脱メチル化酵素 |
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| Research Abstract |
We found that the expression of histone demethylase LSD1 is very low in normal human hematopoietic stem/progenitor cells (HSPC) and considerably higher in AML cells. We identified that only two isoforms were expressed in hematopoietic cells
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[Journal Article] Homopiperazine Homopiperazine derivatives as a novel class of proteasome inhibitors with a unique mode of proteasome binding2013
Author(s)
Kikuchi, J., Shibayama, N., Yamada, S., Wada, T., Nobuyoshi, M., Izumi, T., Akutsu, M., Kano, Y., Sugiyama, K., Ohki, M., Park, S.-Y. and Furukawa, Y
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Journal Title
PLoS One
Volume: 8(4)
Pages: e60649
DOI
Peer Reviewed
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