The role of PI3Kgamma for the pathogenesis of asthma and potentiality for new therapeutic target of asthma

2012 Fiscal Year Final Research Report

• Project/Area Number: 23791097
• Research Category: Grant-in-Aid for Young Scientists (B)
• Allocation Type: Multi-year Fund
• Research Field: 膠原病・アレルギー・感染症内科学
• Research Institution: Akita University
• Principal Investigator: TAKEDA Masahide 秋田大学, 医学部, 助教 (30466594)
• Project Period (FY): 2011 – 2012
• Keywords: PI3K / アレルギー / 喘息 / 好酸球 / eotaxin

Research Abstract

Eosinophils are involved in the pathogenesis of asthma. In this research, we investigated the role of PI3Kgamma for functions of human eosinophils using PI3Kgamma selective inhibitor. As a result, PI3Kgamma selective inhibitor suppressed eotaxin-induced eosinophil migration and activation. This study indicates that PI3Kgamma is involved in human eosinophil function and PI3Kgamma might be new therapeutic target of asthma and allergic diseases.

Research Products

• [Journal Article] アレルギー性炎症における気道構成細胞とイノシトールリン脂質のかかわり (2011)
  • Author(s): 竹田正秀,茆原順一
  • Journal Title: 臨床免疫・アレルギー科 Volume: 56巻2号 Pages: 159-165
• [Presentation] ヒト好酸球の接着能および活性酸素産生に対するPhosphoinositide 3-kinase γの関わり (2012)
  • Author(s): 齊藤由紀子、竹田正秀、植木重治、小林良樹、守時由起、糸賀正道、茆原真実、今野泰典、伊藤亘、茆原順一
  • Organizer: 第62回日本アレルギー学会秋季学術大会
  • Place of Presentation: 大阪
  • Year and Date: 20121100
• [Presentation] The roles of Phosphoinositide 3-kinase gamma for eosinophil functions (2012)
  • Author(s): Takeda M, Saito Y, Ueki S, Konno Y, Chihara M, Itoga M, Moritoki Y, Kobayashi Y, Ito W, Chihara J.
  • Organizer: 31^th Congress of the European Academy of Allergology and Clinical Immunology
  • Place of Presentation: Geneva, Switzerland
  • Year and Date: 20120600
• [Presentation] 好酸球の接着能・顆粒蛋白放出におけるPhosphoinositide 3-kinaseγの関わり (2012)
  • Author(s): 竹田正秀、伊藤亘、齊藤由紀子、植木重治、守時由起、小林良樹、糸賀正道、茆原真実、今野泰典、萱場広之、茆原順一
  • Organizer: 第52回日本呼吸器学会学術講演会
  • Place of Presentation: 神戸
  • Year and Date: 20120400
• [Presentation] ヒト好酸球機能におけるPhosphoinositide 3-kinase gammaの役割 (2011)
  • Author(s): 竹田正秀,伊藤亘,植木重治,今野泰典,茆原真実,糸賀正道,守時由起,小林良樹,萱場広之,茆原順一
  • Organizer: 第40回日本免疫学会学術集会
  • Place of Presentation: 幕張
  • Year and Date: 20111100
• [Presentation] 好酸球細胞機能におけるPhosphoinositide 3-kinaseγの関わり (2011)
  • Author(s): 齊藤由紀子,竹田正秀,伊藤亘,木原純子,植木重治,小林良樹,守時由起,糸賀正道,今野泰典,茆原真実,萱場広之,茆原順一
  • Organizer: 第61回日本アレルギー学会秋季学術大会
  • Place of Presentation: 東京
  • Year and Date: 20111100
• [Presentation] ヒト好酸球の細胞生存および遊走能におけるPhosphoinositide 3-kinaseγの関わり (2011)
  • Author(s): 竹田正秀,伊藤亘,植木重治,木原純子,守時由起,谷貝朋美,糸賀正道,萱場広之,茆原順一
  • Organizer: 第31回日本炎症・再生医学会
  • Place of Presentation: 東京
  • Year and Date: 20110800