2012 Fiscal Year Final Research Report
Autoimmune diseases and the molecular mechanism ofinterleukin -21
| Project/Area Number |
23791099
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Multi-year Fund |
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| Research Field |
膠原病・アレルギー・感染症内科学
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| Research Institution | University of Tsukuba |
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Principal Investigator |
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| Project Period (FY) |
2011 – 2012
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| Keywords | 全身性エリテマトーデス / インターロイキン-21 / T 細胞 |
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| Research Abstract |
Expression of interleukin (IL)-21, IL-21R has enhanced in peripheral blood of patients with systemic lupus erythematosus (SLE), and correlated with serum IgG, and anti-DNA antibody titer. Peripheral blood IL-21 producing cells are follicular helper T-like cells with CXCR5 and ICOS high phenotype. IL-21 producing cellsco-produce IFN-γ, and IL-4, IL-17 was increased in peripheral blood of SLE patients, and negative correlation was observed in the expressionof IL-21 and BAFFR.
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