2012 Fiscal Year Final Research Report
Studies on the mechanism of the tolerance break ofautoimmunity-Analysis of the T cells activation mechanism by epitope spreading-
| Project/Area Number |
23791103
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Multi-year Fund |
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| Research Field |
膠原病・アレルギー・感染症内科学
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| Research Institution | The University of Tokyo |
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Principal Investigator |
SHIBUYA Mihoko 東京大学, 医学部附属病院, 助教 (20366363)
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| Project Period (FY) |
2011 – 2012
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| Keywords | 膠原病学 / エピトープスプレディング |
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| Research Abstract |
We have investigated ‘Extended antigen presentation (EAP)’, a new mechanism of naive T cell activation, using two pairs of cognate antigens and antigen-specific T cells, TEa and OT-II. In this project, we used third antigen-specific T cells; 2D2. With three Tcells model, we proved antigen dependency and universality of EAP.
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