2013 Fiscal Year Final Research Report
The autoantigen TRIM21 as a clinical target for systemic lupus erythematosus
| Project/Area Number |
23791118
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Multi-year Fund |
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| Research Field |
膠原病・アレルギー・感染症内科学
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| Research Institution | Yokohama City University |
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Principal Investigator |
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| Project Period (FY) |
2011 – 2013
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| Keywords | 免疫学 / 内科学 / 膠原病学 |
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| Research Abstract |
The etiology of systemic lupus erythematosus (SLE) or Sjogren's syndrome (SS) still remains unknown. In this study, we investigated the role of TRIM21 and TRIM68, the autoantigens observed in the sera of patients with SLE and SS, in the pathogenesis of these diseases. We clarified that TRIM21 is involved in the ubiquitylation pf TRAF6, an important factor for the NF-kappaB signaling and proinflammatory cytokine production, and that it plays a role in the negative regulation of type I interferon expression. We also observed that TRIM68 interacts with IRF family proteins and ubiquitylates them. These finding suggests that TRIM21 and TRIM68 play an important role for the pathogenesis of SLE and SS. They may have potential as a therapeutic target for these diseases.
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[Presentation] 全身性エリテマトーデスにおける自己抗原TRIM21の役割2014
Author(s)
神山玲光,吉見竜介,國下洋輔,岸本大河,峯岸薫,浜真麻,桐野洋平,浅見由希子,上田敦久,岳野光洋,石ヶ坪良明
Organizer
第58回日本リウマチ学会総会・学術集会
Place of Presentation
東京
Year and Date
2014-04-24
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[Presentation] Autoantigen TRIM21/Ro52 negatively regulates TRAF6 expression via TRIM21-p62-TRAF6 trimer formation2013
Author(s)
Ryusuke Yoshimi, Reikou Kamiyama, Toshinori Tsukahara, Kaoru Minegishi, Maasa Hama, Yohei Kirino, Yukiko Asami, Atsuhisa Ueda, Mitsuhiro Takeno, Herbert C. Morse III, Keiko Ozato, Yoshiaki Ishigatsubo
Organizer
12th International Symposium on Sjögren's Syndrome
Place of Presentation
Kyoto, Japan
Year and Date
2013-10-10
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[Presentation] The E3 ubiquitin ligase TRIM21 promotes degradation of TRAF6 via TRIM21-p62-TRAF6 complex formation2013
Author(s)
Ryusuke Yoshimi, Toshinori Tsukahara, Reikou Watanabe, Maasa Hama, Atsushi Ihata, Atsuhisa Ueda, Mitsuhiro Takeno, Herbert C. Morse III, Keiko Ozato, Yoshiaki Ishigatsubo
Organizer
The Joint International Meeting of The 78thMeeting of The Japanese Society of Interferon and Cytokine Research and The 21st International Symposium on Molecular Cell Biology of Macrophages
Place of Presentation
Tokyo, Japan
Year and Date
2013-05-20
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[Presentation] The E3 ubiquitin ligase TRIM21 forms a complex with p62 and TRAF6 and promotes degradation of TRAF62013
Author(s)
Ryusuke Yoshimi, Reikou Watanabe, Toshinori Tsukahara, Maasa Hama, Atsushi Ihata, Atsuhisa Ueda, Mitsuhiro Takeno, Herbert C. Morse III, Keiko Ozato, Yoshiaki Ishigatsubo
Organizer
The American Association of Immunologists 100th Annual Meeting
Place of Presentation
Honolulu, Hawaii
Year and Date
2013-05-06
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