2013 Fiscal Year Final Research Report
Factors to identify rapid progressive joint destruction and to predict effectiveness of drugs in rheumatoid arthritis
| Project/Area Number |
23791120
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Multi-year Fund |
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| Research Field |
膠原病・アレルギー・感染症内科学
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| Research Institution | Keio University |
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Principal Investigator |
KANEKO Yuko 慶應義塾大学, 医学部, 助教 (60317112)
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| Project Period (FY) |
2011 – 2013
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| Keywords | 関節リウマチ / 関節破壊 / 薬剤効果予測 |
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| Research Abstract |
The aim of this study was to identify factors to predict rapid progressive joint destruction and effectiveness of drugs in rheumatoid arthritis. We demonstrated a significant (p<0.001) reduction of plasma IL-6 but not TNFa during MTX treatment, and that the post-treatment IL-6 level was a strong indicator of radiographic progression. We showed that TRAF1 (+16860A/G) was associated with the clinical response to anti-TNF treatment. Moreover, we showed the population of CD14+CD16+ increased in peripheral blood, and they were related with the rapid radiological progression. Our study indicated the possibility that those factors may enable us to implement personalized treatment.
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[Journal Article] Structural damages disturb functional improvement in patients with rheumatoid arthritis treated with etanercept2012
Author(s)
Tanaka Y, Yamanaka H, Saito K, Iwata S, Miyagawa I, Seto Y, Momohara S, Nagasawa H, Kameda H, Kaneko Y, Izumi K, Amano K, Takeuchi T
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Journal Title
Mod Rheumatol
Volume: 22
Pages: 186-94
DOI
Peer Reviewed
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[Journal Article] Effectiveness and safety of adalimumab in Japanese patients with rheumatoid arthritis : retrospective analyses of data collected during the first year of adalimumab treatment in routine clinical practice (HARMONY study)2012
Author(s)
Takeuchi T, Tanaka Y, Amano K, Hoshi D, Nawata M, Nagasawa H, Sato E, Saito K, Kaneko Y, Fukuyo S, Kurasawa T, Hanami K, Kameda H, Yamanaka H
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Journal Title
Mod Rheumatol
Volume: 22
Pages: 327-38
DOI
Peer Reviewed
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[Journal Article] Clinical, radiographic and functional effectiveness of tocilizumab for rheumatoid arthritis patients-REACTION 52-week study2011
Author(s)
Takeuchi T, Tanaka Y, Amano K, Hoshi D, Nawata M, Nagasawa H, Sato E, Saito K, Kaneko Y, Fukuyo S, Kurasawa T, Hanami K, Kameda H, Yamanaka H
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Journal Title
Rheumatology(Oxford)
Volume: 50
Pages: 1908-15
DOI
Peer Reviewed
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[Presentation] Adding tocilizumab or switching to tocilizumab monotherapy in RA patients with inadequate response to methotrexate : 24-week results from a randomized controlled study (SURPRISE study)2013
Author(s)
Tsutomu. Takeuchi, Yuko Kaneko, Tatsuya Atsumi, Yoshiya Tanaka, M. Inoh, H. Kobayashi, Koichi Amano, M Miyata, Y Murakawa, Takao Fujii, Atushi Kawakami, Hisashi Yamanaka, Kazuhiko Yamamoto, Nobuyuki Miyasaka, Tsuneyo Mimori
Organizer
EULAR 2013-Annual European Congress on Rheumatology
Place of Presentation
Madrid, Spain
Year and Date
20130612-15
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[Presentation] How to Assess Risks for Pulmonary Infection in Patients Receiving Immunosuppressive Treatment for Rheumatic Diseases? A Report From a Large-Scale Prospective Cohort Study2012
Author(s)
Hayato Yamazaki, Ryoko Sakai, Ryuji Koike, Yasunari Miyazaki, Michi Tanaka, Toshihiro Nanki, Kaori Watanabe, Shinsuke Yasuda, Takashi Kurita, Yuko Kaneko, Yoshiya Tanaka, Yasuhiko Nishioka, Yoshinari Takasaki, Kenji Nagasaka, Koichi Amano, Shigeto Tohma, Makoto Dohi, Takahiko Sugihara, Haruhito Sugiyama, Yasushi Kawaguchi, Naohiko Inase, Sae Ochi, Hiroyuki Hagiyama, Nobuyuki Miyasaka, Masayoshi Harigai
Organizer
American College of Rheumatology 76th Annual Meeting
Place of Presentation
Washington
Year and Date
20121109-14
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[Presentation] Evaluation of clinical, structural and functional remission in rheumatoid arthritis patients treated with tocilizumab in daily clinical practice -sub analysis of the Reaction study by disease duration-2011
Author(s)
Tsutomu Takeuchi, Yoshiya Tanaka, Koichi Amano, Eichi Tanaka, Masao Nawata, Hayato Nagasawa, Daisuke Hoshi, Kazuyoshi Saito, Shunsuke Fukuyo, K Hanami, Hideto Kameda, Takahiko Kurasawa, Yuko Kaneko, Hisashi Yamanaka
Organizer
EULAR 2011-Annual European Congress on Rheumatology
Place of Presentation
London, United Kingdom
Year and Date
20110525-28
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[Presentation] TNF Inhibitors reduced structural changes to"ZERO"in patients with rheumatoid arthritis, as interium report of ZERO-J study2011
Author(s)
Yoshiya Tanaka, Hisashi Yamanaka, Takao Koike, Nobuyuki Miyasaka, Tsuneyo Mimori, Tsutomu Takeuchi, Takayuki Sumida, Kazuhiko Yamamoto, Shintaro Hirata, Masao Nawata, Shunsuke Fukuyo, Eiichi Tanaka , Kosaku Murakami, Yuko Kaneko, Kazuyoshi Saito
Organizer
EULAR 2011-Annual European Congress on Rheumatology
Place of Presentation
London, United Kingdom
Year and Date
20110525-28
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[Presentation]2011
Author(s)
Michi Tanaka, Yoshiya Tanaka, Makoto Doi, Yasushi Kawaguchi, Yoshinari Takasaki, Hideto Kameda, Shigeto Tohma, Yasuhiko Nishioka, Shinsuke Yasuda, Naohiko Inase, Yuko Kaneko, Ryoko Sakai, Toshihiro Nanki, Ryuji Koike, Kaori Watanabe, Hayato Yamazaki, Nobuyuki Miyasaka, Masayoshi Harigai
Organizer
1st Symposium of the Asia Pacific League of Associations for Rheumatology(APLAR2011)
Place of Presentation
Taipei, Taiwan
Year and Date
20110315-17
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