2013 Fiscal Year Final Research Report

The effect of macrolide antibiotics on co-infection of influenza virus and Strepto-coccus pneumoniae in mice.

Research Project

Project/Area Number	23791139
Research Category	Grant-in-Aid for Young Scientists (B)
Allocation Type	Multi-year Fund
Research Field	Infectious disease medicine
Research Institution	Nagasaki University
Principal Investigator	MORITA Towako (永田永田) 長崎大学, 医歯(薬)学総合研究科, 客員研究員 (50569960)
Project Period (FY)	2011 – 2012
Keywords	感染症防御学 / インフルエンザウイルス
Research Abstract	Secondary bacterial pneumonia is one of the complications in patients with influenza virus infection. Macrolide antibiotics (MCLs) are known to have immunomodulatory effects beyond antibacterial activity and recently reported to have direct effect on influenza epidemic. Based on these backgrounds, the aim of our study was to determine the inhibitory effect of macrolide antibiotics on coinfection of influenza virus and S. pneu-moniae in mice. We conclude that CAM improved survival time of influenza virus and S. pneumoniae coinfection mice model and that CAM could play a beneficial role in influenza virus and S. pneumoniae coinfection by inducing Th1 cytokines and suppressing PAF receptor expression.