2013 Fiscal Year Final Research Report
Evaluation between gene-polymorphism and efficacy of therapy for pulmonary arterial hypertension using next-generation DNA analysis system
| Project/Area Number |
23791144
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Multi-year Fund |
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| Research Field |
Pediatrics
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| Research Institution | Asahikawa Medical College |
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Principal Investigator |
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| Project Period (FY) |
2011 – 2013
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| Keywords | 肺高血圧症 / 先天性心疾患 |
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| Research Abstract |
We studied pulmonary arterial hypertension in children with congenital heart disease. Serum high sensitivity cTnI levels significantly correlated with Pp/Ps in children. The Qs and Qp/Qs obtained by MRI strongly correlated with those obtained by catheterization, and a significant correlation was observed between the MCFR and Pp/Ps. Moreover, unlike patients with regressed CALs (coronary arterial lesion) in Kawasaki Disease, patients with persistent CALs have abnormal mechanical properties and hemodynamics of the pulmonary artery.
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