2012 Fiscal Year Final Research Report
The analysis of CD33 antigens expressed in acute lymphoblastic leukemia
| Project/Area Number |
23791158
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Multi-year Fund |
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| Research Field |
Pediatrics
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| Research Institution | University of Yamanashi |
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Principal Investigator |
AKAHANE Koshi 山梨大学, 医学部附属病院, 助教 (90377531)
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| Project Period (FY) |
2011 – 2012
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| Keywords | 急性リンパ性白血病 / 骨髄球系抗原 / CD33 / E2A-HLF |
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| Research Abstract |
We previously reported frequent expression of myeloid antigen CD33 on t(17;19)-ALL, which shows the poorest outcome in childhood ALL, and that E2A-HLF fusion transcription factor derived from t(17;19) induces CD33 expression. The objective of this study is to elucidate the mechanism of CD33 expression ALL. We found that the PEA3 binding sites located downstream of the start site of CD33gene are important for the induction by E2A-HLF and confirmed that this mechanism is also essential forCD33 expression in both Philadelphia chromosome-positive ALL and ALL with 11q23 chromosomal translocations, which are representative refractory childhood ALLs.
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Research Products
(1 results)
