2013 Fiscal Year Final Research Report
Disease specific therapy for polycystic kidney disease based on EMT
| Project/Area Number |
23791190
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Multi-year Fund |
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| Research Field |
Pediatrics
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| Research Institution | Wakayama Medical University |
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Principal Investigator |
TOGAWA Hiroko 和歌山県立医科大学, 医学部, 助教 (30445093)
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| Project Period (FY) |
2011 – 2013
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| Keywords | 遺伝性腎疾患 / 多発性嚢胞腎 / 上皮間葉移行 / CPKマウス / TGF-β / Smad3 / 疾患特異的治療 |
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| Research Abstract |
Epithelial mesenchymal transition (EMT) is thought to be involved in pathophysiology of polycystic kidney disease (PKD). We determined a signal transduction of EMT in PKD in this study and examined possibility of pathophysiology-specific therapy that targeted the signal transduction.
In CPK mouse, qualitative rather than quantitative abnormality was present in the TGF-beta/Smad3 system, and enhanced expression of c-Myc by intranuclear pSmad3L/C effects through JNK/CDK4 was shown. Furthermore, we made Smad3 knock-out and CPK double mutant and examined changes of the disease phenotype by modification of Smad3. With these findings, we obtained the basic data for disease-specific therapy developments.
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[Presentation] Smad3 Phosphorylated at Both Linker and COOH-Terminal Regions in Cyst-Lining Epithelia in cpk Mouse, a Model of ARPKD2013
Author(s)
Hama T, Nakanishi K, Mukaiyama H, Togawa H, Sato M, Shima Y, Miyajima M, Nozu K, Nagao S, Takahashi H, Iijima K, Yoshikawa N
Organizer
46^<th> Annual Meeting of the American Society of Nephrology
Place of Presentation
Atlanta, USA
Year and Date
20131107-10
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[Presentation] Possible contribution of fibrocytes to renal fibrosis in cpk mouse, a model of ARPKD2013
Author(s)
Hama T, Nakanishi K, Mukaiyama H, Sato M, Togawa H, Shima Y, Miyajima M, Takahashi H, Nagao S, Iijima K, Yoshikawa N
Organizer
15th Congress of the International Pediatric Nephrology Association
Place of Presentation
Shanghai, China
Year and Date
20130830-0903
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[Presentation] cpkマウス多発性嚢胞腎モデル腎線維化におけるfibrocyteの関与2013
Author(s)
浜武継,中西浩一,向山弘展,佐藤匡,戸川寛子,島友子,宮嶋正康,高橋久英,長尾静子,飯島一誠,吉川徳茂
Organizer
第48回日本小児腎臓病学会学術集会
Place of Presentation
徳島
Year and Date
20130628-29
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[Presentation] cpkマウスARPKDモデルにおける病的Smad3リン酸化2013
Author(s)
浜武継,中西浩一,向山弘展,戸川寛子,佐藤匡,島友子,宮嶋正康,野津寛大,高橋久英,長尾枝澄香,飯島一誠,吉川徳茂
Organizer
第21回嚢胞性腎疾患研究会
Place of Presentation
東京
Year and Date
2013-09-21
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[Presentation] cpkマウスにおける病的Smad3リン酸化2013
Author(s)
浜武継,中西浩一,向山弘展,戸川寛子,佐藤匡,島友子,宮嶋正康,野津寛大,高橋久英,長尾枝澄香,飯島一誠,吉川徳茂
Organizer
第22回発達腎研究会
Place of Presentation
高槻
Year and Date
2013-09-14
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[Presentation] Possible Contribution of Fibrocytes to Renal Fibrosis in Cpk Mouse, a Model of ARPKD2012
Author(s)
Hama T, Nakanishi K, Mukaiyama H, Togawa H, Shima Y, Miyajima M, Takahashi H, Nagao S, Iijima K, Yoshikawa N
Organizer
45^<th> Annual Meeting of the American Society of Nephrology
Place of Presentation
San Diego, USA
Year and Date
20121101-04
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[Presentation] Acceleration of Smad3 phosphorylation at linker regions via c-Jun NH2-terminal kinase (JNK) in cyst-lining epithelial cells in cpk mouse, a model of ARPKD2011
Author(s)
Mukaiyama H, Nakanishi K, Hama T, Togawa H, Shima Y, Miyajima M, Takahashi H, Nagao S, Iijima K, Yoshikawa N
Organizer
44^<th> Annual Meeting of the American Society of Nephrology
Place of Presentation
Philadelphia, USA
Year and Date
20111108-13
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[Presentation] cpkマウスARPKDモデルにおける上皮間葉移行(EMT)2011
Author(s)
向山弘展,中西浩一,戸川寛子,濵武継,島友子,宮嶋正康,吉原大輔,長尾枝澄香,高橋久英,飯島一誠,吉川徳茂
Organizer
第54回日本腎臓学会学術総会
Place of Presentation
横浜
Year and Date
20110615-17
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