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2013 Fiscal Year Final Research Report

Disease specific therapy for polycystic kidney disease based on EMT

Research Project

  • PDF
Project/Area Number 23791190
Research Category

Grant-in-Aid for Young Scientists (B)

Allocation TypeMulti-year Fund
Research Field Pediatrics
Research InstitutionWakayama Medical University

Principal Investigator

TOGAWA Hiroko  和歌山県立医科大学, 医学部, 助教 (30445093)

Project Period (FY) 2011 – 2013
Keywords遺伝性腎疾患 / 多発性嚢胞腎 / 上皮間葉移行 / CPKマウス / TGF-β / Smad3 / 疾患特異的治療
Research Abstract

Epithelial mesenchymal transition (EMT) is thought to be involved in pathophysiology of polycystic kidney disease (PKD). We determined a signal transduction of EMT in PKD in this study and examined possibility of pathophysiology-specific therapy that targeted the signal transduction.
In CPK mouse, qualitative rather than quantitative abnormality was present in the TGF-beta/Smad3 system, and enhanced expression of c-Myc by intranuclear pSmad3L/C effects through JNK/CDK4 was shown. Furthermore, we made Smad3 knock-out and CPK double mutant and examined changes of the disease phenotype by modification of Smad3. With these findings, we obtained the basic data for disease-specific therapy developments.

  • Research Products

    (12 results)

All 2013 2012 2011

All Journal Article (1 results) Presentation (11 results)

  • [Journal Article] 髄質嚢胞腎.腎臓症候群(第2版)-その他の腎臓疾患を含めて-2012

    • Author(s)
      戸川寛子,中西浩一,吉川徳茂
    • Journal Title

      別冊日本臨床新領域別症候群シリーズ

      Volume: 17 Pages: 600-602

  • [Presentation] Smad3 Phosphorylated at Both Linker and COOH-Terminal Regions in Cyst-Lining Epithelia in cpk Mouse, a Model of ARPKD2013

    • Author(s)
      Hama T, Nakanishi K, Mukaiyama H, Togawa H, Sato M, Shima Y, Miyajima M, Nozu K, Nagao S, Takahashi H, Iijima K, Yoshikawa N
    • Organizer
      46^<th> Annual Meeting of the American Society of Nephrology
    • Place of Presentation
      Atlanta, USA
    • Year and Date
      20131107-10
  • [Presentation] Possible contribution of fibrocytes to renal fibrosis in cpk mouse, a model of ARPKD2013

    • Author(s)
      Hama T, Nakanishi K, Mukaiyama H, Sato M, Togawa H, Shima Y, Miyajima M, Takahashi H, Nagao S, Iijima K, Yoshikawa N
    • Organizer
      15th Congress of the International Pediatric Nephrology Association
    • Place of Presentation
      Shanghai, China
    • Year and Date
      20130830-0903
  • [Presentation] cpkマウス多発性嚢胞腎モデル腎線維化におけるfibrocyteの関与2013

    • Author(s)
      浜武継,中西浩一,向山弘展,佐藤匡,戸川寛子,島友子,宮嶋正康,高橋久英,長尾静子,飯島一誠,吉川徳茂
    • Organizer
      第48回日本小児腎臓病学会学術集会
    • Place of Presentation
      徳島
    • Year and Date
      20130628-29
  • [Presentation] 常染色体劣性多発性嚢胞腎の鑑別を要した3例2013

    • Author(s)
      浜武継,中西浩一,佐藤匡,向山弘展,戸川寛子,島友子,辻本弘,神波信次,吉川徳茂
    • Organizer
      第35回日本小児腎不全学会学術集会
    • Place of Presentation
      郡山
    • Year and Date
      2013-10-24
  • [Presentation] cpkマウスARPKDモデルにおける病的Smad3リン酸化2013

    • Author(s)
      浜武継,中西浩一,向山弘展,戸川寛子,佐藤匡,島友子,宮嶋正康,野津寛大,高橋久英,長尾枝澄香,飯島一誠,吉川徳茂
    • Organizer
      第21回嚢胞性腎疾患研究会
    • Place of Presentation
      東京
    • Year and Date
      2013-09-21
  • [Presentation] cpkマウスにおける病的Smad3リン酸化2013

    • Author(s)
      浜武継,中西浩一,向山弘展,戸川寛子,佐藤匡,島友子,宮嶋正康,野津寛大,高橋久英,長尾枝澄香,飯島一誠,吉川徳茂
    • Organizer
      第22回発達腎研究会
    • Place of Presentation
      高槻
    • Year and Date
      2013-09-14
  • [Presentation] Possible Contribution of Fibrocytes to Renal Fibrosis in Cpk Mouse, a Model of ARPKD2012

    • Author(s)
      Hama T, Nakanishi K, Mukaiyama H, Togawa H, Shima Y, Miyajima M, Takahashi H, Nagao S, Iijima K, Yoshikawa N
    • Organizer
      45^<th> Annual Meeting of the American Society of Nephrology
    • Place of Presentation
      San Diego, USA
    • Year and Date
      20121101-04
  • [Presentation] cpkマウスにおける部位特定的リン酸化Smad3の発現2012

    • Author(s)
      向山弘展,中西浩一,浜武継,戸川寛子,島友子,宮嶋正康,高橋久英,長尾枝澄香,飯島一誠,吉川徳茂
    • Organizer
      第47回日本小児腎臓病学会学術集会
    • Place of Presentation
      東京
    • Year and Date
      20120629-30
  • [Presentation] Acceleration of Smad3 phosphorylation at linker regions via c-Jun NH2-terminal kinase (JNK) in cyst-lining epithelial cells in cpk mouse, a model of ARPKD2011

    • Author(s)
      Mukaiyama H, Nakanishi K, Hama T, Togawa H, Shima Y, Miyajima M, Takahashi H, Nagao S, Iijima K, Yoshikawa N
    • Organizer
      44^<th> Annual Meeting of the American Society of Nephrology
    • Place of Presentation
      Philadelphia, USA
    • Year and Date
      20111108-13
  • [Presentation] cpkマウスARPKDモデルにおける上皮間葉移行(EMT)2011

    • Author(s)
      向山弘展,中西浩一,戸川寛子,濵武継,島友子,宮嶋正康,吉原大輔,長尾枝澄香,高橋久英,飯島一誠,吉川徳茂
    • Organizer
      第54回日本腎臓学会学術総会
    • Place of Presentation
      横浜
    • Year and Date
      20110615-17
  • [Presentation] cpkマウスにおける部位特定的リン酸化Smad3の発現2011

    • Author(s)
      浜武継,中西浩一,向山弘展,戸川寛子,島友子,宮嶋正康,高橋久英,長尾枝澄香,飯島一誠,吉川徳茂
    • Organizer
      第19回嚢胞性腎疾患研究会
    • Place of Presentation
      東京
    • Year and Date
      2011-09-11

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Published: 2015-06-25  

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