2013 Fiscal Year Final Research Report
A study regarding gene expressions of Sirt1 in human placentas of newborns with intrauterine growth restriction
| Project/Area Number |
23791224
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Multi-year Fund |
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| Research Field |
Embryonic/Neonatal medicine
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| Research Institution | Kobe University |
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Principal Investigator |
MORIOKA ICHIRO 神戸大学, 医学研究科, 特命教授 (80437467)
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| Project Period (FY) |
2011 – 2013
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| Keywords | 子宮内胎児発育不全 / 遺伝子 / 血管内皮増殖因子 / レニン・アンジオテンシン系 / 多型 / 脂質 |
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| Research Abstract |
A purpose of this study was to investigate expressions of Sirt1 gene in human placentas of newborns with intrauterine growth restriction (IUGR). No different expressions of Sirt1 gene were found between IUGR and appropriate-for-gestational age newborns. However, we found that the vascular endothelial growth factor and renin-angiotensin system gene polymorphisms are at risk for developing IUGR in Japanese newborns.
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