2013 Fiscal Year Final Research Report
Stem cell therapy for neonatal hypoxia-ischemia
| Project/Area Number |
23791229
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Multi-year Fund |
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| Research Field |
Embryonic/Neonatal medicine
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| Research Institution | Ehime University |
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Principal Investigator |
ZHU Pengxiang 愛媛大学, 医学(系)研究科(研究院), 助教 (40380216)
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| Project Period (FY) |
2011 – 2013
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| Keywords | 新生児医学 / 脳性麻痺 / 再生医学 / 胚性幹細胞 / 神経前駆細胞 |
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| Research Abstract |
Neonatal hypoxic-ischemic insult is one of the most significant cause of pediatric encephalopathy and spastic cerebral palsy. Although the developing brain's plasticity allows for remarkable self-repair, severe disruption of normal myelination and cortical development upon neonatal brain injury are likely to generate life-persisting sensory-motor and cognitive deficits in the growing child. Currently, no treatments are available that can address the long-term consequences. Thus, regenerative medicine appears as a promising avenue to help restore normal developmental processes in affected infants. Here we have demonstrated that neural stem cells derived from embryonic stem cells have shown protective effects on hypoxic-ischemic insults. Our results have suggested that stem cell therapy has proven effective in promoting functional recovery in animal models of neonatal hypoxic-ischemic injury and therefore represents a hopeful therapy for this unmet medical condition.
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