2013 Fiscal Year Final Research Report

Basic research for the oscillations of the brain metabolism in neonates: analysis of the relationship between NIRS and EEG.

Research Project

Project/Area Number	23791240
Research Category	Grant-in-Aid for Young Scientists (B)
Allocation Type	Multi-year Fund
Research Field	Embryonic/Neonatal medicine
Research Institution	Kurume University
Principal Investigator	OHYA Takashi 久留米大学, 医学部, 助教 (70333234)
Project Period (FY)	2011 – 2013
Keywords	NIRS / LFOs / trace alternant
Research Abstract	Low frequency oscillations (LFOs), which are defined as frequencies between 0.01-0.1 Hz, have increasingly recognized using monitoring cerebral blood flow, metabolism and function. Previous report ,which investigated NIRS and EEG in preterm infants, found pronouncing coherence between LFOs and burst activities during the trace alternant EEG phase. They concluded that NIRS-LFOs might be the consequence of BOLD phenomenon induced by oxygen consumption during burst activities. The aim of this study was to investigate the relationship between electro-cortical activities and NIRS-LFOs during every sleep stages in healthy neonates. We measured 13 records. The results were as below, we confirmed the correlation between electro-cortical activities and NIRS-LFOs, the power of NIRS-LFOs was observed every sleep stages. Because NIRS-LFOs occurred without electro-cortical activities, it suggested the existence of the origin of electro-cortical activities and LFOs in oxygen availability.