2012 Fiscal Year Final Research Report
Control of spindle orientation in skin basal cells by c-Abland possible role of calcium signaling in spindle orientation
| Project/Area Number |
23791265
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Multi-year Fund |
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| Research Field |
Dermatology
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| Research Institution | Kyoto University |
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Principal Investigator |
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| Project Period (FY) |
2011 – 2012
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| Keywords | 細胞分裂軸 / 皮膚基底細胞 / ABL1 |
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| Research Abstract |
We performed a genome-scale RNA-mediated interference screen of human kinases using the HeLa cell system and identified ABL1 tyrosine kinase as a novel regulator for spindle orientation in mammalian cells. We find that ABL1 regulates spindle orientation not only in HeLa cells but also in mouse epidermis. Furthermore, we found that ABL1 regulates spindle orientation through LGN and NuMA, which form an evolutionarily conserved regulatory complex for spindle orientation.
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