2012 Fiscal Year Final Research Report
SSRI administration during adolescent period and suicide risk-serotonin receptors and impulsivity
| Project/Area Number |
23791305
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Multi-year Fund |
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| Research Field |
Psychiatric science
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| Research Institution | Hokkaido University |
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Principal Investigator |
OHMURA Yu 北海道大学, 大学院・医学研究科, 助教 (80597659)
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| Project Period (FY) |
2011 – 2012
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| Keywords | SSRI |
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| Research Abstract |
In the present study, we attempted to determine a cause of increased suicide risk due to serotonin reuptake inhibitor (SSRI) administration at adolescent period, focusing on the dysfunction of serotonin receptors and SSRI-induced impulsivity. We successfully developed a behavioral task to assess impulsivity in adolescent rats. The co-administration of a 5-HT2C receptor antagonist and SSRI enhanced impulsivity. However SSRI administration unaltered impulsivity in 5-HT2C receptor knockout mice, inconsistent with above rat study. Thus we were not able to obtain a clear conclusion.
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