Biological basis and possible tailor-made therapy of developmental disabilities with problematic social behavior

2014 Fiscal Year Final Research Report

• Project/Area Number: 23791327
• Research Category: Grant-in-Aid for Young Scientists (B)
• Allocation Type: Multi-year Fund
• Research Field: Psychiatric science
• Research Institution: Nagoya University
• Principal Investigator: OKADA Takashi 名古屋大学, 医学部附属病院, 准教授 (80335249)
• Research Collaborator: USAMI Masahide 国立国際医療研究センター, 国府台病院, 医師 ; SUGIYAMA Yuka 名古屋大学, 医学部附属病院精神科, 医師 ; MORIKAWA Mako 名古屋大学, 大学院医学系研究科
• Project Period (FY): 2011-04-28 – 2015-03-31
• Keywords: 行動障害 / 社会認知 / 実行機能 / 神経基盤 / コピー数変異 / 併存障害 / 薬物療法 / 行動療法

Outline of Final Research Achievements

Children and adolescents with autism spectrum disorders (ASD), attention-deficit hyperactivity disorders (ADHD), or major depressive disorders were examined by standardized questionnaires. As a result, their social behavioral disturbances were associated with ADHD symptoms or oppositional defiant behavior, and partly with ASD tendency or depressive state. These results indicates the relationship between symptomatology of developmental disorders and social behavioral disturbances. Neuropsychological basis of mental disorders with social behavioral disturbances were examined; exploratory eye movement, attention shift for gaze direction and executive functions. In addition, we analyzed a large number of DNA samples, and reported part of the findings. We review a large number of previous studies and propose a guideline on the intervention for social behavioral disturbances. Further studies are needed to develop a tailor-made therapy.

Free Research Field

児童精神医学