Functional analysis of schizophrenia riskgene CHI3L1

2012 Fiscal Year Final Research Report

• Project/Area Number: 23791331
• Research Category: Grant-in-Aid for Young Scientists (B)
• Allocation Type: Multi-year Fund
• Research Field: Psychiatric science
• Research Institution: Osaka University
• Principal Investigator: YAMAMORI Hidenaga 大阪大学, 大学院・医学系研究科, 寄附講座助教 (90570250)
• Project Period (FY): 2011 – 2012
• Keywords: 統合失調症 / CHI3LI / 脳表現型

Research Abstract

We recently reported a significant association between schizophrenia and SNP rs4950928, which is located in the promoter region of the CHI3L1 gene, in a Japanese population. The aim of this study is to see the effect of CHI3L1 gene on various phenotypes of brain, like neurocognition, neuroimaging, neurophysiology, personality trait and gene expressions. We also investigated the differential expression of this gene in schizophrenia. We found the differential expression of CHI3L1 gene in schizophrenia. We also found the association between the risk SNP and the personality trait; Self-Transcendence or the expression of this gene and protein.

Research Products

• [Journal Article] The regulation of gene expression involved in TGF-β signaling by ZNF804A, a risk gene for schizophrenia (2013)
  • Author(s): Umeda-Yano S, Hashimoto R, Yamamori H, Okada T, Yasuda Y, Ohi K, Fukumoto M, Ito A, Takeda M.
  • Journal Title: Schizophr Res
  • DOI: doi:10.1016/j.schres
• [Journal Article] The AKT1 gene is associated with attention and brain morphology in schizophrenia (2013)
  • Author(s): Ohi K, Hashimoto R, Yasuda Y, Fukumoto M, Nemoto K, Ohnishi T, Yamamori H, Takahashi H, Iike N, Kamino K, Yoshida T, Azechi M, Ikezawa K, Tanimukai H, Tagami S, Morihara T, Okochi M, Tanaka T, Kudo T, Iwase M, Kazui H, Takeda M
  • Journal Title: World J Biol Psychiatry Volume: 14(2) Pages: 100-13
  • DOI: doi:10.3109/15622975.2011.591826
  • Peer Reviewed
• [Journal Article] The KCNH2 gene is associated with neurocognition and the risk of schizophrenia (2013)
  • Author(s): Hashimoto R, Ohi K, Yasuda Y, Fukumnoto M, Yamamori H, Kamino K, Morihara T, Iwase M, Kazui H, Takeda M
  • Journal Title: World J Biol Psychiatry Volume: 14(2) Pages: 114-20
  • DOI: doi:10.3109/15622975.2011.604350
  • Peer Reviewed
• [Journal Article] Analysis of the VAV3 as candidate gene for schizophrenia: evidences from voxel based morphometry and mutation screening (2012)
  • Author(s): Aleksic B., Kushima I, Hashimoto R, Ohi K, Ikeda M, Yoshimi A, Nakamura Y, Ito Y, Okochi T, Fukuo Y, Yasuda Y, Fukumoto M, Yamamori H, Ujike H, Suzuki M, Inada T, Takeda M, Kaibuchi K, Iwata N, Ozaki N
  • Journal Title: Schizophrenia Bulletin
• [Journal Article] Takeda M.Expression analysis of a novel mRNA variant of the schizophrenia risk gene ZNF804A (2012)
  • Author(s): Okada T, Hashimoto R, Yamamori H, Umeda-Yano S, Yasuda Y, Ohi K, Fukumoto M, Ikemoto K, KUnii Y, Tomita H, Ito A
  • Journal Title: Schizophr Res Volume: 141(2-3) Pages: 277-8
  • DOI: doi:10.1016/j.schres.2012.08.015
  • Peer Reviewed
• [Journal Article] Personality traits and schizophrenia: evidence from a case-control study and meta-analysis (2012)
  • Author(s): Ohi K, Hashimoto R, Yasuda Y, Fukumoto M, Yamamori H, Iwase M, Kazui H, Takeda M.
  • Journal Title: Psychiatry Research Volume: 198(1) Pages: 7-11
  • DOI: doi;10.1016/j.psychres.2011.12.018
  • Peer Reviewed
• [Journal Article] Functional genetic variation at the NRGN gene and schizophrenia: evidence from a gene-based case-control study and gene expression analysis (2012)
  • Author(s): Ohi K, Hashimoto R, Yasuda Y, Fukumoto M, Yamamori H, Umeda-Yano S, Okada T, Kamino K, Morihara T, Iwase M, Kazui H, Numata S, Ikeda M, Ohmura T, Iwata N, Ueno S, Ozaki N, Ohmori T, Arai H, Takeda M
  • Journal Title: American Journal of Medical Genetics Part B: Neuropsychiatric Genetics Volume: 159B(4) Pages: 405-13
  • DOI: doi:10.1002/ajmg.b.32043
  • Peer Reviewed
• [Journal Article] The p250GAP Gene is Associated with Risk for Schizophrenia and Schizotypal Personality Traits (2012)
  • Author(s): Ohi K, Hashimoto R, Nakazawa T, Okada T, Yasuda Y, Yamamori H, Fukumoto M, Umeda-Yano S, Iwase M, Kazui H, Yamamoto T, Kano M, Takeda M
  • Journal Title: PLoS One Volume: 7(4) Pages: e35696
  • DOI: doi:10.1371/journal.pone.0035696
  • Peer Reviewed
• [Journal Article] A promoter variant in the Chitinase 3-Like 1 gene is associated with serum YKL-40 level and personality trait (2012)
  • Author(s): Yamamori H, Hashimoto R, Ohi K, Yasuda Y, Fukumoto M, Kasahara E, Sekiyama A, Umeda-Yano S, Okada T, Iwase M, Kazui H, Ito A, Takeda M
  • Journal Title: Neurosci Lett Volume: 513(3) Pages: 204-208
  • Peer Reviewed
• [Presentation] 阪大病院における 23 症例の治療抵抗性統合失調症患者へのクロザピンの使用経験:副作用によって中止した症例のの転帰について (2012)
  • Author(s): 山森英長、橋本亮太、安田由華、福本素由己、大井一高、藤本美智子、武田雅俊
  • Organizer: 第22回日本臨床精神神経薬理学会第42回日本神経精神薬理学会合同年会
  • Place of Presentation: 栃木、ポスター
  • Year and Date: 20121018-20
• [Presentation] 統合失調症患者死後脳における、GWAS で報告された統合失調症関連遺伝子の発現解析-Expression analysis of schizophrenia risk genes identified in GWAS using post mrtem brain- (2012)
  • Author(s): 山森英長、橋本亮太、梅田知美、Cyndi Shannon Weickert、安田由華、大井一高 、福本素由己、藤本美智子、伊藤彰、武田雅俊
  • Organizer: 第34回日本生物学的精神医学会
  • Place of Presentation: 神戸、ポスター
  • Year and Date: 20120928-30
• [Presentation] Expression analysis of the genes identified by GWAS in postmortem brain tissues from BPD and SZ. (2012)
  • Author(s): Yamamori H, Hashimoto R, Umeda-Yano S, Yasuda Y, Ohi K, Ito A, Takeda M
  • Organizer: The 2nd Meeting of East Asisan Bipolar Forum(2nd EABF)
  • Place of Presentation: Fukuoka,口演
  • Year and Date: 20120907-08
• [Presentation] Schizophrenia associated promoter variant in the Chitinase 3-Like 1 gene is associated with serum YKL-40 level and personality trait (2011)
  • Author(s): 山森英長、橋本亮太、大井一高、安田由華、福本素由己、梅田知美、岩瀬真生、数井裕光、伊藤彰、武田雅俊
  • Organizer: 第33回日本生物学的精神医学会
  • Place of Presentation: 東京、ポスター
  • Year and Date: 20110521-22
• [Book] 統合失調症入院プログラムにおける治療抵抗性統合失調症に対するclozapine の 有用性、臨 床精神 薬理 (2012)
  • Author(s): 橋本亮太、山森英長、安田由華、福本素由己、大井一高、井上頌子、竹上学、武田雅俊
  • Total Pages: 15:1841-1855
  • Publisher: 星和書店