2012 Fiscal Year Final Research Report
The relationship between oligodendrocyte loss in the juvenile period and the onset of schizophrenia
| Project/Area Number |
23791348
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Multi-year Fund |
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| Research Field |
Psychiatric science
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| Research Institution | Tottori University |
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Principal Investigator |
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| Research Collaborator |
IKAWA Daisuke 奈良県立医科大学, 医学部, 大学院生
HIROTA Naoya 奈良県立医科大学, 医学部, 大学院生
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| Project Period (FY) |
2011 – 2012
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| Keywords | 統合失調症 / Olig2 |
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| Research Abstract |
We hypothesized that oligodendrocyte loss in the juvenile period may influence the onset of schizophrenia, and we focused on the function of Olig2, play an important role in the differentiation of oligodendrocyte. To test the hypothesis, we used double transgenic mice, which can reduce the expression of Olig2 in the juvenile period. The results were that there have not significant differences in our experimental status. We thought that the double transgenic mice were not performed sufficient recombination in our experimental status
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